Uphucula iziPhumo zexesha elide
Amachiza e-naltrexone sele abe yonyango oluchanekileyo lwezonyango ngenxa yobunxila ngenxa yokuba kusebenza ukunciphisa imiphumo yemichiza enokusetyenziswa kotywala kwindawo yengqondo.
Enye yeemvavanyo zonyango ezivunyiweyo zonyango lokuxhomekeka kotywala, i- naltrexone isetyenziselwe iminyaka ukunceda abantu abaye bayeka ukusela ukuze baphephe ukuphindaphinda.
I-Naltrexone iphinde iphumelele ekuphatheni abantu abaye banomlutha we-opioids, i- heroin kwaye uphando kwi- cocaine . Ukwenza oko ngokuthintela umphumo opioids onamaziko ajabulisayo wengqondo. I-Naltrexone kumanqanaba amancinci isetyenziselwa ukunyanga iintlungu ezibangelwa zizimo ezifana ne-fibromyalgia kunye nesifo esingapheliyo.
Iingxaki NgePilisi Yemihla ngemihla
Ukunyangwa kweengxaki zokusetyenziswa kotywala , i-naltrexone yayimiselwe ngokusemthethweni njengepilisi yemihla ngemihla idlalwa malunga neveki ezingama-12, kwaye i-naltrexone kwifom yefilda-ithengiswa njengeRevia kunye ne-Depade-isasetyenziswa kakhulu.
Nangona kunjalo, kukho ingxaki yendalo kunye nefilisi ye-naltrexone - ukuba isebenze, abantu abayilungiselelwe ukunceda kufuneka bathabathe imithi yonke imihla. Kulabo bajamelana nemiphumo yokuphuza utywala kunye nokusetyenziswa kotywala , ukuthotyelwa kokuthatha i-dose yemihla ngemihla kunokuba yingxaki.
Ukuthatha ixesha elide, Ukunyuka kweNyanga
Le ngxaki yaqwalaselwa xa abaphandi baqala ukujonga uhlobo olutsha lwe-naltrexone oluya kutsalwa kanye kwaye lukhutshwe kancinci kwinkqubo yenyanga.
Enye yezifundo zaqhutyelwa kwiYunivesithi yaseNorth Carolina kwiChapel Hill kwaye yabandakanyeka izigulane ezingama-624 ezazisetyenziselwa ukuphazamiseka kokusetyenziswa kotywala kwizibhedlele, VA
iikliniki kunye namaziko ezeMpilo eMelika.
Zonke izigulane ziphuza ngokunyanisekileyo, kodwa ziphathwe ngenxa yokusela utywala.
Ukunciphisa iiNtsuku zokuNxila
Abathathi-nxaxheba babejojowe nge-380 mg. ye-naltrexone ende ende, 190 mg. ye-naltrexone, okanye unike ijoke ye-placebo. Iilenki zanikezelwa rhoqo ngenyanga kwaye amaqela amabini afumana iiseshoni zokungenwa kwengqondo ezingaphantsi kwama-12.
Uphononongo lufumene ukuba umthamo we-380 mg we-naltrexone wabangela ukunciphisa u-25% weentsuku zokuphuza, ngelixa umthamo we-190 mg wanciphisa iintsuku zokusela ezininzi 17%.
Abaphandi bazimisele ukuba amadoda aphendule kwi-naltrexone unyango ngaphezu kwabesetyhini kwaye ukuba abo bagulane abaye bafunda kwisithuba esithile sokuzila bafumana unyango olungakumbi.
Ezinye Iimpawu Zecala, Kodwa Zibukhali
Kulabo bathatha umthamo we-380-mg, i-14.1% yashiywe ngaphandle kwonyango ngenxa yeempembelelo zecala, kubandakanywa isicupunu, intloko kunye nokukhathala. I-6.7% kuphela yeqela elifumana u-190 mg unyango oluyekile ngenxa yemiphumo emibi.
Uvavanyo lwaseNorth Carolina lunye lwezilingo ezinkulu kunazo zonke eziphathwe ngamachiza ekuxhomekeke kotywala. Izigqibo zabaphengululi zithi ukukhululwa kwexesha elide le-naltrexone kwakuxhomekeke kakuhle kwaye kuncitshiswe kakhulu ukusela kakhulu kwizigulana zokusela.
UVivitrol evunywe yi-FDA
Uphando lufumanise ukuba uhlobo olude lwe-naltrexone lunokuphucula izicwangciso zonyango malunga nezidakila ngokuphelisa umyalelo wokuthotyelwa kweyeza kunye nokubonelela "isiseko se-pharmacological basis".
Esi sifundo kunye nabanye babenomdla kwiSatifikethi se-US Food and Drug Administration ngo-Ephreli 2006 ukuba bavume unyango lwe-naltrexone lunye-nenyanga - oluthengiswa njengeVivitrol - ukusetyenziswa njengonyango lokuxhomekeka kotywala.
Imithombo:
Garbutt, JC, et al. Umlingo oLawuliweyo olungaphendulwanga we-Naltrexone engama-long-acting Injectable for Alcohol Dependence. " Umbhalo we-American Medical Association ngo- Ephreli 2005
ILayibrari yeSizwe ka-US yamayeza. "I-Naltrexone Iziyobisi, iIrbs and Supplements ." NgoNovemba 2010