Ithintela njani iimpembelelo ze-opioids kwaye iyanciphisa utywala
I-Naltrexone yi-opioid receptor antagonist esetyenzisiweyo ngokuyinhloko ekulawuleni ukuxhomekeka kotywala kunye ne-opioid addiction. I-Naltrexone hydrochloride ithengiswa phantsi kwegama lohlobo lweRevia kunye ne-Depade. Ifomu yokukhululwa kweNaltrexone ithengiswa phantsi kwegama le-Vivitrol .
Ukusetyenziswa
Kubantu abayeke ukusela, i-Naltrexone inciphisa ukufunwa kotywala abantu abaninzi abaxhomekeke kutywala xa beyeka ukusela.
Ayiqondi kakuhle ukuba i-Naltrexone iyanciphisa njani ukufunwa kotywala, kodwa ezinye izazinzulu zikholelwa ukuba kusebenza ngokunciphisa imiphumo yokuphuza utywala kwiindlela ezithile zobuchopho. Le ndlela ibandakanya i-neurotransmitter dopamine .
I-Naltrexone isebenza ngokuthintela imiphumo yezilwanyana ezifana ne-heroine kunye ne-cocaine kwingqondo, nayo. Njenge-opioid receptor antagonist, iNaltrexone ikhusela nje ukuphendula ngokuqhelekileyo kwengxenye yengqondo evelisa umva wokonwaba opioids.
Isistim
Ifomu yepilisi, i-Naltrexone idla ngokumiselwa ukuba ithathwe kanye ngosuku. Izifundo zijonge ukusetyenziswa kweNaltrexone kwixesha leveki ezili-12 ukunceda abantu baye bayeka ukusela ukuze banciphise ukulangazelela kotywala ngexesha lokuqala lokuziyeka xa umngcipheko wokuphindaphinda ungowona mkhulu, nangona ungasetyenziselwa ixesha elide ekwenzeni kliniki. Ngenxa yokuba i-Naltrexone ivimbela iziphumo ze-opioids, ngamanye amaxesha imiselwe ixesha elide kubantu abazama ukulawula ukuxhomekeka kweziyobisi .
Ngomhla ka-Ephreli 2006, i-FDA ivume i - Naltrexone ifom ye- injection ye-Naltrexone, eyathengiswa njengeVivitrol, ukwenzela unyango lokuxhomekeka kotywala . Uphando oluthile lwabonisa ukuba ifom ye-Naltrexone yanyanga zonke yayilungelelanise ukugcina ubumbele kwipilisi ngoba iphelisa ingxaki yokuthotyelwa kwamachiza.
Ukufakela ngokutsha kweDetoxification
Ifomu yokufakelwa kwe-Naltrexone isetyenziselwa kwinkqubo ephikisanayo ebizwa ngokuba yi-detoxification ngokukhawuleza yokuxhomekeka kwe-opioid. Kwi-detox esheshayo, ubeka phantsi kwe-anesthesia jikelele kunye nokufakelwa kwe-Naltrexone kufakwa kwi-esiswini sakho esezantsi okanye emva kwesithuba. Le nqubo ivame ukulandelwa ngamayeza e-Naltrexone kwiinyanga ezili-12.
I-FDA ayizange ifake iifom ye-Naltrexone. Nangona inkqubo ye-detox ngokukhawuleza iphakanyiswa njengexesha elilodwa "unyango" lomlutha weziyobisi, uphando luye lwabonisa ukuba lusebenza kakuhle njengenyathelo lokuqala kwinkqubo yokuvuselela ixesha elide.
Imiphumela
I-Naltrexone inokubangela isisu esisisulu, ukwesaba, ukuxhalaba, okanye intlungu kunye nentlungu. Ngokuqhelekileyo, ezi zimpawu zincinci kwaye zisesigxina, kodwa kubantu abathile, zinokuba nzima kwaye zihlala zihlala zihlala zihlala zihlala zihlala zihlala zihlala zihlala zihlala zihlala zihlala zihlala zihlala zikhona.
Kwiimeko ezinqabileyo, i-Naltrexone ibangela iziphumo ezibi kakhulu ezibandakanya ukudideka, ukulala, ukucabisa, ukuhlanza, isisu esiswini , ukugqithisa kwesikhumba, isifo sohudo, okanye umboniso otyumkileyo. Xhagamshelana nogqirha wakho ngokukhawuleza ukuba unayo nayiphi na yale mpawu.
Amanani amakhulu eNaltrexone angabangela ukuhluleka kwesibindi. Kumelwe uyeke ukuthatha i-Naltrexone ngokukhawuleza ukuba unayo nayiphi na impawu ezilandelayo: ukhathala ngokweqile, ukuphaphazeka okungavamile okanye ukutyumla, ukulahleka kwesidlo, intlungu ephezulu kwinxalenye yesisu, umchamo omnyama, okanye ukuphuka kwesikhumba okanye amehlo.
Funda uluhlu olupheleleyo lweempawu kwisilumkiso esashicilelwe kwi-packaged Naltrexone.
Iinkcazo
I-Naltrexone imiselwe kuphela emva kokuyeka ukusela utywala okanye ukuthatha i-opioids iintsuku ezisixhenxe ukuya kwele-10 kuba kunokubangela ukuba iimpawu ezinokuthi zihoxise xa zithathwa xa usasebenzisa iziyobisi.
Abantu abane-hepatitis, isibindi okanye isifo sesifo akufanele bathathe iNaltrexone. Izigulane ezisetyenziselwa ukuguqula i-narcotic painkillers akufanele zithathe kwaye akufuneki nabani na ochasayo nakwezinye iziyobisi. Abasetyhini abakhulelweyo okanye abancelisayo akufanele bathathe iNaltrexone.
I-Naltrexone ayincedi umntu ukuba ayeke ukusela okanye ukusebenzisa iziyobisi-isetyenziselwa ukunceda abantu abaye bayeka ukugcina ukuziyeka.
Ayenzi uphatha iimpawu zokurhoxiswa kotywala okanye iziyobisi.
Impumelelo
Uphando luye lwabonisa ukuba iNaltrexone inokunciphisa ukulangazelela utywala kunye neziyobisi kwabanye abantu, kodwa ayisebenzi kuwo wonke umntu. Njengoko unyango oluninzi lwezobisi lweziyobisi kunye nokusetyenziswa kakubi kweziyobisi , lisebenza kakuhle xa lusetyenziswa ngokuphathelele kwinkqubo yonyango jikelele, njengonyango lwe-psychosocial, ukucebisa, okanye iqela lokuxhasa inxaxheba.
I-Naltrexone "ayiphilisi", kodwa isincede abaninzi banomdla wokusela utywala okanye ukusetyenziswa kweziyobisi ukuzinqanda ngokunciphisa ukuthanda kwabo utywala okanye iziyobisi.
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