Izidakamizwa zamachiza ziyaziwa ukuba zisebenzisane nezinye iziyobisi kunye nokutya ezithile, kodwa ziyakuthi zichaphazeleke ukuyeka ukutshaya nokutshaya.
Indlela ezinye izidakamizwa zonyango ezichaphazela ngayo i-cigarette smoke
Ukutya esikutyayo kuphuhliwe (i-metabolized) zibe zondlo ezizisebenzisayo. Le nqubo iqala nge-enzymes, ezenza njengezinto zokukhusela kwinkqubo yokutya.
Zininzi iintlobo zeenzyme. Abanye babo bancedisa ukuwaphula amaprotheni, omnye umsebenzi kwi-carbohydrates, kunye nabanye kumafutha.
Ngendlela efanayo, kukho i-enzymes ejongene nokusetyenziswa kwezidakamizwa. Enye yale enzyme, i-CYP1A2, ichaphazeleka ngamanye amakhemikhali kumsi wecuba. Ezi ngxube, ezibizwa ngokuthi i-PAHs (i-polycyclic hydrocarbons ephosakeleyo) ziyaziwa ngokuba ezinye zegciwane ezinamandla kunomsi wocuba .
Xa ii-PAH zidibanisa ne-CYP1A2 i-enzyme iyasebenza. Oku kubangela ukuba amayeza aphulwe yi-CYP1A2 ukuba ahlaziywe ngokukhawuleza kunokuba afanele abe. Ngenxa yoko, ababhemayo badla ngokufuna idosi ephezulu kunokuba ingaqhelekanga.
Xa utshaya luyeka ngokukhawuleza, njengokungena esibhedlele apho ukutshaya kungavunyelwe okanye ukuyeka ukutshisa okubandayo, umsebenzi we-CYP1A2 uyancipha kwaye umthamo omkhulu unokugqithiswa ngokukhawuleza. Ilungelo lemiphumo emibi yemichiza yanda ngokukhawuleza.
Kubalulekile ukuba amayeza ahlaziywe kwaye mhlawumbi alungiswe ngugqirha wokumisela xa umntu eyeka ukutshaya.
Iidakamizwa zeMithi eLawulayo i-CYP1A2
Njengoko unokubona kuloluhlu, uluhlu oluhlukahlukeneyo lwemithi luye lwenziwa nge-CYP1A2. Ezinye zazo aziyi kubangela impendulo engalunganga emva kokuyeka ukutshaya, kodwa ezinye zingabangela imiphumo emibi xa idosi ingaguquki okanye ihlengahlengiswe xa umntu eyeka ukutshaya.
Unganqikazi ukwabelana nohambo lwakho lokuyeka ukubhema kunye neqela lakho lononophelo lwezempilo ukuze bakwazi ukugcina iliso nayiphi na inguqu enokuthi uyenze.
- I-Alosetron (iLotronex): i-antidiarrheal esetyenziselwa ukunyanga isifo sengqondo segazi
- I-Clozapine: iziyobisi ezisetyenziswayo ukuphatha i-schizophrenia
- I-Flutamide (Eulexin): i-hormone-based based chemotherapy
- I-Fluvoxamine (Luvox): isetyenziselwa ukunyanga ukuziphatha okugqithisileyo okanye ukunyanzelisa
- I-Frovatriptan (Frova): isetyenziselwa ukuphatha i-migraine ikhanda
- I-Haloperidol (iHaldol): iyakhathaza i-schizophrenia, i-psychosis esichukumisayo, kwaye isetyenziselwa iifiksi kunye namazwi omlomo we-Tourette's syndrome
- Imipramine (eTofranil): isetyenziselwa ukuphatha uxinzelelo
- I-Melatonin: ngaphezu kweseyile yokuxhaswa esetyenziselwa ukulala
- I-Mexiletine (Mexitil): i-antiarrhymic esetyenziselwa ukuphatha intliziyo engaqhelekanga
- I-Mirtazapine (Remeron): i-antidepressant esebenzisa ukuphathwa kwengcinezelo.
- I-Olanzapine (iZyprexa): isetyenziselwa i-schizophrenia, i-bipolar disorder
- Ipropanolol (Inderal): isetyenziselwa ukuphatha iingcazo, i-angina (intlungu yesifuba), uxinzelelo lwegazi oluphezulu, ukukhathazeka kwentliziyo, kunye nezinye iintliziyo okanye iimeko ezijikelezayo. Kwakhona kusetyenziselwa ukuphatha intloko ye-migraine
- I-Ramelteon (Rozerem): isondlo esisetyenziselwa ukulala
- I-Rasagiline (Azilect): i-MAOI kunye ne-anti-depressant engasetyenziswa ekuphatheni isifo sika-Parkinson
- I-Ropinirole (Ixhoba): umgqugquzeli we-dopamine ongasetyenziselwa ukuphatha isifo sika-Parkinson kunye nesifo sengqondo esingenasiphelo
- I-tacrine (Cognex): isetyenziselwa ukuphatha isifo se-Alzheimer
- Theophylline: ukulawula i-asthma yexesha elide
- I-Tizanidine (Zanaflex): i-muscle ephumayo esetyenziselwa ukunyanga ama-muscle spasms
- I-Triamterene (iDyrenium): i-diuretic isetyenziselwa ukugcinwa kwamanzi kunye nokunyuswa kwegazi
- I-Zolmitriptan (Zomig): i-triptan isetyenziselwa ukuphatha intloko ye-migraine
I-Caffeine Ibuye yaxhaswa yi-CYP1A2
Abaninzi ababhemayo baya kukuxelela ukuba ikhofi inefuthe elomeleleyo kubo emva kokuyeka ukutshaya. Inkomfa eqhelekileyo okanye amabini ekuseni ishiya i-jittery kunye nexhala.
Baye bawutyelele ukungabi nicotine , kwaye loo nto idlala indima, kodwa mhlawumbi yayinokwenza ngakumbi ngeCYP1A2.
Ababhemayo bahlaziya i-caffeine malunga namaxesha amane kwizinga labangabhemi. Akumangalisi ukuba ukusela isonka esiqhelekileyo okanye esinye isiphuzo se-caffeinated ngokukhawuleza akukhathazi emva kokuyeka ukutshaya. Ukuba usandula ukuyeka, ungase uzame ukusika i-caffeine yakho ngomlinganiselo kwaye ubone indlela ozivakalelwa ngayo. Unako ukunciphisa okanye ukwandisa ngokusekelwe kuloo nto.
Iicotin kunye neMigqirha yamayeza
I-Nicotine kwicuba kunye nakwi-nicotine unyango olutshintsho lunokuchaphazela nendlela umzimba okwazi ukuphendula ngayo amanye amayeza.
I-Nicotine ithatha imithwalo yegazi kwaye inokuvimbela ukutsalwa kwe-insulin shots.
I-Nicotine iyakhuthaza iphakamisa izinga lentliziyo kunye nexinzelelo lwegazi. Inokubangela ukunciphisa ububele kumachiza asetyenziswa ukuphatha okufanayo. Kudibaniswa kunye nokunciphisa i-sedation evela kwi-benzodiazepines (i-tranquilizers) kunye nokukhululeka kwentlungu e-opioids.
Cwangcisa utyunjwa noDokotela wakho
Ukuba uthatha nayiphi na imishanguzo yemithi kwaye unqume ukutshaya (okanye uceba ukwenza), jonga kunye nogqirha wakho ukuphonononga indlela abanokuchaphazeleka ngayo ukuyeka ukutshaya.
Iindaba ezilungileyo kukuba ukuyeka ukutshaya kuya kuphucula impilo yakho kunye nobukhulu. Unokufumanisa ukuba amanye amayeza angasuswa xa umzimba wakho ufumana ukutshaya kwe-nicotine .
Ukuba ulungele ukuyeka, sebenzisa ezi zinto ukuyeka ukutshaya izibonelelo njengendawo yokuqala. Akukho xesha nje njengamanje ukuqala umsebenzi ukwenza amaphupha akho abe yinyani.
Imithombo:
I-Australian Prescriber. UkuHlangana nokuThengiswa kweziMilo. https://www.nps.org.au/australian-prescriber/articles/smoking-and-drug-interactions.
AmaFesmacy Times. Yazi i-Enzyme: CYP1A2. http://www.pharmacytimes.com/publications/issue/2007/2007-11/2007-11-8279.