Utywala luvimbela ukuQongwa kwama-Osteoblasts
Kuzo zonke iziphumo zokusetyenziswa kotywala obunzima kwexesha elide, mhlawumbi uncinci ukwazi ukuba ukusela okunzima kunokuchaphazela njani ubunzima bomzimba emzimbeni.
Uphando luye lwabonisa ukuba ukusetyenziswa kakubi kotywala kunokuba negalelo ekunciphiseni ukutyunjwa kwamathambo, ukunyuka kwamanani kunye nokulibaziseka ekuphulukisweni kwezifucu, kodwa uphando oluncinane luyenziwe kwiphulo lotywala ekuphuhliseni amathambo amatsha.
Ukuphuhliswa kunye nomsebenzi we-osteoblasts, iiseli ezintsha zethambo, ziyimngcipheko ethile yokuphuza izidakamizwa ezibangelwa utywala, ezinokukhokelela ekunciphiseni i-bone and form mass mass.
Abaphengululi kwi-Omaha Veterans Medical Centre Centre bafumene ukuba ukusela okungapheliyo kunye nokunxila kunokuba lunqande ukubunjwa kwe-osteoblasts.
Utywala lubuthinta i-Bone Remodeling
"Ukugcinwa kwethambo eliphilileyo kubantu abadala kubangelwa kwinkqubo ebizwa ngokuthi 'ithambo lokulungisa,' kutsho uDennis A. Chakkalakal, uphando loososayensi kwi-Omaha Veterans Medical Centre Centre, unjingalwazi onxulumene kwisebe lophando kwiYunivesithi yaseCreighton, kunye nombhali oyedwa lokuhlaziywa. "Ngaliphi na ixesha ngexesha lokuphila kwabantu abadala, kwaye kwiindawo ezahlukahlukeneyo zamathambo, iincinci ezincinci 'zethambo elidala' zisuswa ngamaseli abizwa ngokuthi 'i-osteoclasts,' kwaye ithambo elitsha lenziwa ngamaseli abizwa ngokuthi 'osteoblasts.' Ngomntu onempilo, le mi sebenzi emibini ibhalisele ukuze kungabikho ukulahleka kwethambo. "
Nangona kunjalo, uChakkalakal wabika ukuba ukusela okungapheliyo kunye nokuphuza kakhulu kunokuphazamisa ukulinganisela ngokuphelisa amathambo amatsha.
Isithuba esingenanto esenziwe ngumsebenzi oqhelekileyo wokususa amathambo azalisekanga ngethambo elitsha, "kusho uChakkalakal. "Le nkqubo iyaqhubeka kwezinye iisayithi zamathambo ngexesha lomjikelezo olandelayo wokulungiswa.
Impembelelo ephezulu yale nkqubo ngexesha leenkqubo ezinokulungiswa kwezinto ezininzi zibonakaliswa njengelahleko elincincikayo lokulahlekelwa kwethambo ngexesha leminyaka embalwa nje. "
Ukwanda kweNgcakano yeNkunkuma
Iziphumo eziphambili zovavanyo lwe-Omaha ziquka:
- "Ukuphuza i-bone-stimulated bone disease" kubhekisela kwimiphumo emibili yokusetyenziswa kakubi kakubi kotywala : ukulahleka kwethambo (eyaziwa nge-osteopenia), oku kubangela ukwanda komngcipheko; kunye nokulahleka kweethambo.
- I-osteopenia eyenziwe ngotywala ihlukile kwi-post-menopausal osteoporosis kwaye iyisebenzise i-osteoporosis.
- Ucwaningo lwabantu, isilwanyana kunye neeseli lubonisa ukuba iziphumo ezinobungozi zotywala kwi-osteoblast imisebenzi zixhomekeke kumthamo.
- Utywala luyakunqanda ukuveliswa kwematrix engenakususwa, ephazamisa ukuphulukana nokuphulwa.
- Ukulahleka kwethambo etywala utywala kuhambelana nokungaqhelekanga kweseli ye-cell in the bone.
Utywala luchaphazela umsebenzi we-Osteoblast
"Ukuthetha ngokubambisana, ubungqina bubonisa ukuba kukho intambo edibeneyo edibanisa ukungahambi kakuhle, njengokulahleka kwethambo kunye nokuphulukisa amathambo, kunye nokusetyenziswa kakubi kokusela ngokweqile ," kusho uChakkalakal.
"Kwiimeko zombini, utywala lubangathintela umsebenzi we-osteoblast, ngaloo ndlela ugxothisa amathambo amatsha afunekayo kwiimeko eziqhelekileyo zokuphucula amathambo kunye nokuphulukana nokuphulukana," watsho.
Sifuna iimfuno zexesha elizayo ezijoliswe kwiinkqubo zee molecular ezithintela ngayo utywala ovimba umsebenzi we-osteoblast. Sifuna kwakhona ukuhlolisiswa kwemiphumo yezinye izinto ezinjengokungondleki, ukutshaya nokungazinzi izinto ezibonakalayo njengoko kukho izifundo ezimbalwa ezivavanya iziphumo ezi zinto. "
"Ekugqibeleni, sifuna iziphumo ezicacileyo, ezilungiselelwe kakuhle ukulungisa ukungafani kwexesha kunye nolwabiwo kwimiphumo yokuxilisa nokusetyenziswa ngokweqile kotywala," kusho uChakkalakal.
Ukuzilahla Okukhethileyo Okukhethiweyo
"Ukuhlaziywa kugxininisa ukubaluleka kokuziyeka ukusela utywala ngezigulana - utywala okanye i-teetotalers - kunye neziqhekeza kwaye ngubani onokufuna ukusela ngexesha lokugqithisa," kusho u-VA Research Career Scientist uTerrence M.
Donohue, Jr.
Imithombo:
Chakkalakal, DA. "Utywala-Yenza Ukulahleka Kwemfuyo Nefuthe Elixhomekeke Kwamathambo." Utywala: Uphando lwezonyango kunye novavanyo lukaDisemba 2005