I-Genetics ye-Bipolar Disorder
Ukuba unentsholongwane ye-bipolar kwaye ucinga ukuba nezingane, enye ye mibuzo ocinga ukuba uyazibuza ukuba ingaba uyayidlulisela ingxaki yakho ye-bipolar kumntwana. Ngaba i-bipolar disorder inherited? Yiyiphi indima yezofuzo kwi-bipolar disorder?
Ngaba i-Bipolar Disorder Hereditary?
Siyazi ixesha elithile ukuba ingxaki ye-bipolar ingaqhutyelwa kwiintsapho, kwaye ngoku, kunye nokulandelana kwe-genomic, sifunda malunga nenxaxheba ebonakalayo yemfuza kwi-disorder.
Nangona indima yobuncwane ibonakala ngokucacileyo kwiintsapho kunye nama-twin izifundo, uphando oluqhubekayo lufunekayo.
Umngcipheko wobomi obunzima wokuphucula i-bipolar disorder kucatshangwa ukuba uphakathi kwe-1 ne-4 ekhulwini, kuxhomekeke kwintetho, ngokwexesha eliqhelekileyo lokuxilongwa kwe-18.
Makhe sijonge into esiyayazi ngembali yentsapho kunye nengxaki ye-bipolar, kwaye ngoko kwiingcali zezofuzo zifumene malunga nendima yemvelo yentsholongwane kunye neengxaki zempilo yengqondo.
Imbali Yentsapho Yengxaki Yobungqina Bipolar
I-bipolar disorder ibhekwa njengento enye yeengxaki eziphambili zempilo yengqondo esekelwe ukuhlaziywa kweeseshati zomlando zentsapho. Ngokomzekelo, nantsi idatha esuka kwisifundo esifumene nokuxhamla kwentsapho ephezulu nengxaki ye-bipolar:
- Umntwana womzali omnye onentsholongwane ye-bipolar kunye ne-without one unama-15 kuya kwe-30 ekhulwini ithuba lokuba ne-BP.
- Ukuba ngaba abazali bobabini banenkinga yokuphazamiseka kwengqondo, kukho i-50 ukuya kuma-75 ekhulwini amathuba okuba umntwana wabo, naye.
- Ukuba sele unomntwana omnye kunye ne-BP, kukho ithuba eli-15 kuya kwangu-25 ithuba lokuba enye yabantwana bakho iya kuba nayo.
- Ukuba elinye iwele lifana ne-BP, kukho malunga nama-85 ekhulwini amathuba lokuba omnye uya kuhamba. Kwiminye emithathu yezifundo, ithuba lokuba newele elifanayo kunye neengxaki ze-bipolar ukusuka kuma-38 ukuya kuma-43 ekhulwini kunye namawele e-dizygotic (angafaniyo) aphakathi kwama-4.5 ne-5.6 ekhulwini.
Ezinye iziphumo ezininzi ziye zafumanisa ukuba i-bipolar disorder iqhutyelwa kwiintsapho, nangona kungabikho bonke kule nqanaba. Iinkalo ezithile zeengxaki ze-bipolar nazo zibonakala ziqhutyelwa kwiintsapho eziquka ukugqithisa kokugula ( ukukhangela ukuxineka), ubukhulu beengqungquthela, ubukho be- psychosis , ukuzibulala, ukuhamba ngokuhamba ngokukhawuleza, ukuxhatshazwa kokusetyenziswa kotywala, ukuphazamiseka kwentlanzi kunye nokuphendula (okanye ukungabi naso) kwimithi efana ne-lithium kunye nezinye iziyobisi.
Ubunzima bokuqala kwesifo sengqondo se-bipolar kaninzi selula kubantwana abanobazali okanye oogogo nomkhulu abaneengxaki ezibangelwa yi-bipolar.
I-Genetics vs Environment kunye ne-Bipolar Disorder (i-Nature vs Oppression Confroversy)
Xa i-bipolar disorder iqhutyelwa kwiintsapho icela umbuzo: Ngaba ukwanda kwengozi ehambelana nobomi (ukuhlanganiswa kwemfuza ethile) okanye endaweni yendawo. Kubonakala ukuba zombini iindlela zidlalwa kwaye zenza igalelo le -bipolar disorder .
I-Genetics ye-Bipolar Disorder
Nangona kuqhutyelwa kwiintsapho, kunzima ukuchaza izinto ezithile zobungozi bokuzalwa. Izifundo ezijonge i-genetics ye-bipolar disorder ziye zahluleka ukufumana i-gene esisodwa esenza i-causative (umzekelo, njengokuba kunjalo ne-cystic fibrosis.) Kunoko, kubonakala ukuba kukho imimandla ethile ye-chromosomal eneendiza ezininzi (i-polygenic,) nganye enesiphumo esincinci ekuphakanyiseni ukukhutshwa kweengxaki.
Iintsholongwane kwiijethi ezifana ne-ANK3, i-CACNA1C, i-NCAN, i-ODZ4 kwaye kucatshangelwa ukuba zandise ukukhusela kodwa zichaze kuphela ipesenteji encinci yemingcipheko yofuzo. Ukongezelela, uninzi lwabantu abanalo "abasemngciphekweni" abasenayo ingxaki yokuguquka kwengqondo.
I-Genetics kunye neempendulo kwiMithi ye-Bipolar
Umba ohlukeneyo oye waphawula ngokuqonda kwethu kwintsholongwane yemvelo kukuba i-genetics ingadlala indima kwindlela umntu asabela ngayo kumachiza okuphazamiseka kwengqondo. Ngokomzekelo, abo abaneekhophi ezimbini ezingasebenziyo ze-CYP206 i-gene ingaba yi-pooraboli yezilwanyana ezinobungozi ezifana ne-respiradone kunye ne-aripiprazole.
Njengoko kuphawuliwe ngasentla, ubungakanani bomntu osabela kwiziyobisi ezifana ne-lithium inokuthi isebenze kwintsapho.
I-Genetics ye-Bipolar Disorder nezinye izifo zeMpilo yengqondo
Ekujongeni ukukhuselwa kwemvelo, kuye kwaphawulwa ukuba yabo iyahlukana phakathi kohlobo lwemizi echazwe ngentsholongwane ye-bipolar kunye ne- schizophrenia , isifo se-schizoaffective kunye nokudandatheka .
Ngaba Ngaba Unayo Abantwana Ukuba Unayo I-Bipolar Disorder?
Ukwazi ukuba kukho ingozi eyingozi yokwenza i-bipolar disorder kubantwana balabo abaneengxaki zokugula ngengqondo, ngaba ngaba abazali abanenkinga abanezingane?
Lo ngumbuzo ongenayo impendulo engalunganga okanye engalunganga. Kukho imeko ezininzi zonyango ezinokuthi zibe nelifa. Ukongezelela, akukho mnye umgubo okanye ulandelelwano lwemizimba "oluqinisekisa" umntwana uya kuhlakulela ingxaki ye-bipolar.
Kubalulekile ukuba uqaphele ukuba akukho nto ithi ukuba nomntwana ophuhlisa ingxaki yempilo yengqondo akuyi kuba ngamava amanelisayo.
Impendulo echanileyo yinto abazali abaya kuyigqiba ngayo kukulungele bona bobabini kunye nabantwana babo kwikamva. Ukwazi ukuba unembali yentsapho, nangona kunjalo, lunokunceda kakhulu ekubekeni iliso umntwana wakho kufuneka abonise iimpawu okanye iimpawu ukuze aqaphele imeko ngaphambi kokuba isiqhelo se-mania senzeke.
Ngaphantsi kwi-Genetics, Heredity, ne-Bipolar Disorder
Kubonakala kucacile ukuba kukho indima yezofuzo ekuphuhliseni ukuphazamiseka kwe-bipolar, kodwa le nxaxheba ibonakala iyinxalenye ye-polygen (ilawulwa kancane kancane ngeendidi ezininzi ezahlukeneyo) kwaye iyinkimbinkimbi kakhulu. Ngamanye amazwi, akukho nto enye okanye yezinto ezahlukeneyo ezibangelwa ukuphazamiseka kwe-bipolar, kunoko, ukudibanisa kweendiza ezinokuthi zandise amandla omntu wokuphucula ukukhubazeka kwe-bipolar. Imbali yentsapho yengxaki ayikho isizathu sokuyeka ukuba ngumzali. Unokufisa ukufunda ngeeflegi ezibomvu zentsholongwane ye-bipolar kubantwana , kunye neendlela ezahlukeneyo zesifo .
> Imithombo:
> Alsabban, S., Rivera, M., kunye noP. McGuffin. I-Genome-Wide Search i-Bipolar Disorder Genes. Iingxelo zengqondo zengoku . 2011. 13 (6): 522-7.
> Charney, A., Ruderfer, D., Stahl, E. et al. Ubu bungqina beHeterogeneity ye-Genetic Phakathi kweeNtsholongwane zeBipolar Disorder. Psychiatry yokuguqulela . 2017. 7 (1): e993.
> Craddock, N., kunye noP. Sklar. I-Genetics ye-Bipolar Disorder. Lancet . 2013. 381 (9878): 1654-62.
> Uhamba, F. I-Genetics ye-Bipolar Disorder: I-Update Update kunye neZikhokelo zeKamva. Iiklinikhi zeengqondo zeNyakatho Melika . 2016. 39 (1): 139-55.
> Kerner, B. Ukuqonda ngokujulile kwe-Genetics ye-Bipolar Disorder. Umda weeNzululwazi . 2015. 6: 105.