Ukukhubazeka ngokuzenzekelayo kungabangela iimpawu ezinjenge-bipolar-like
I-systemic lupus erythematosus (eyaziwa nangokuthi i-lupus okanye i-SLE) yintlupheko yomsindo ongenza izifo ezingapheliyo kwiindawo ezahlukeneyo zomzimba. Nangona iifayile eziqhelekileyo ze-lupus aziwa, imeko ekugqibeleni imele i-immune system ishiyiwe, ihlasele iiseli eziqhelekileyo ezibonayo ngephutha.
Inkqubo yesiseko senzwa yinye yeethagethi zalo mpendulo.
Xa kwenzeka, iyakwazi ukubonakalisa iimpawu zengqondo ezixhatshaza ngokufana neengxaki ze-bipolar .
Nangona iimpawu zeengxaki ezimbini zihamba (njengokuba izidakamizwa zisetyenziselwa ukuzenza), i-SLE kunye ne-bipolar ayikho into ehambelana nayo. Nangona kukho inkolelo eninzi, i-SLE ayibangeli imbandezelo ye-bipolar.
Ngakolunye uhlangothi, i-SLE ngezinye izihlandlo i-SLE ingabonwa njengengxaki yokuphazamiseka kwe-bipolar. Xa oku kwenzeka, umntu angabonakaliswa kwindlela yokwelashwa engadingekanga kwaye engafanelekanga.
Iimpawu ze-Neuropsychiatric zeLupus
Xa i-lupus ithintela inkqubo ye-nervous central, ingabangela iimpawu ezahlukahlukeneyo, zombini neurolotiki. Sibhekisela kule meko njenge-neuropsychiatric systemic lupus erythematosus (NPSLE). Iimpawu ziyakwazi ukusuka kwi-mild to severe and include:
- Intloko
- Izifo zengqondo, kuquka ukuxinezeleka kunye neempawu ze-bipolar
- Ukulahleka kwememori
- Ukulahlekelwa komsebenzi wokuqonda
- Ukugubha, i-tics, kunye nenkuthazo yokuzibandakanya
- Ukucima okanye ukungaqiniseki
- Ukuxhamla
- Umbono ongezantsi
- Ukuva iingxaki
- Iingxaki zokuthetha
- Ukudideka kunye neerrium
- Ukulinganisa, ukuphazamiseka, ukutshisa, ukukhathazeka kwemizwa
- Stroke
I-NPSLE ichaphazela malunga neepesenti ezingama-40 zabantu abane-lupus, esoloko ibonakalisa ukuxinezeleka, ukulahleka kwememori, kunye nokuhla kwezinto eziqhelekileyo. Kuthathwa njengengxaki enzulu ekhokelela ekunciphiseni umgangatho wobomi kunye nokugula okwandisiweyo.
Uphando lwangoku lubonisa ukuba i-NPSLE idibene nokunyuka kwexesha elilishumi ekufeni ngokuthelekiswa nabantu kubonke abantu.
Izizathu zeNPSLE
Esikhundleni sokuba nesinye isizathu esithile, i-NPLSE ibangelwa kukudibanisa kwezinto ezibandakanya ukungasebenzi komzimba, iziphene ze-hormonal, ukuvuvukala kwamathambo, kunye nokulimala ngokuthe ngqo kwimizimba yesifo. Kwaye nemiphumo emibi yeziyobisi ingabangela iimpawu. Ngaphezu koko, isiseko sokukhusela esijikeleze ingqondo, esibizwa ngokuba ngumqobo weengqondo, sinokuphazamiseka yi-lupus, ukuvumela ukuba i-toxins ingene kwaye imonakalise izicubu ze-neural.
Ezinye zeempawu ze-NPLSE zinokudityaniswa nemeko ebizwa ngokuba yi-demyelinating syndrome apho impendulo engaphenduliyo ngokukhawuleza ikhupha i-myelin sheath (cinga nje ngekhava ekhuselayo) yentsholongwane. Ngokuxhomekeka apho oku kwenzeka khona, kunokubangela iintlobo ezahlukeneyo zengqondo, ingqiqo kunye neengxaki ezibonakalayo.
Ukuxilongwa kweNPSLE
Ngenxa yokuba kunzima ukuhlula phakathi kwezizathu ezahlukahlukeneyo ze-NPSLE (kubandakanywa nezifo ezizimeleyo zengqondo), akukho mgangatho wegolide wokuxilongwa. Ngaloo ndlela, ukuxilongwa ngokuqhelekileyo kwenziwa ngokukhutshwa, ukuhlolisisa zonke izizathu ezinokwenzeka kubandakanye ukusuleleka, izifo, kunye nemiphumo emibi yeziyobisi.
Oku kwenziwa kwimeko-nge-imeko phantsi kolawulo lwenzululwazi efumanekayo kwi-NPSLE.
Ukuba i-demyelination syndrome ikhunjulwa, iimvavanyo zingenziwa ukwenzela ukuba ziqinisekise ukuba zikhona izixhobo zamanqwanqwa ezizimele (autoantibodies) ezinxulumene nomonakalo we-myelin.
Unyango lweNPLSE
Ukuthetha ngokuqhelekileyo, amayeza asetyenziswa ekuphatheni izifo zengqondo kunye nemizwelo ingasetyenziselwa ukunyanga iimpawu zeengqondo ze-lupus.
Xa kwenzeka i-NPSLE enzima, unyango luya kugxininiswa ekusebenziseni amayeza anciphisa kwaye athatyathe impendulo yokuzimela. Izinketho ziquka i-corticosteroids ephezulu-dose (njenge-prednisone okanye i-dexamethasone ene-cyclophosphamide ene-intravenous).
Ezinye iindlela zonyango eziqhelekileyo ziquka i-rituximab, i-immunoglobulin (inyilo) yonyango, okanye iplasmapheresis (i-plasma dialysis). Iimpawu ezincinci zokumodareyitha zingaphathwa nge-azathioprine yomlomo okanye i-mycophenolate.
Kubalulekile ukuba uqaphele, nangona kunjalo, ukuba amanani aphakamileyo e-corticosteroids angadala ukukhathazeka kwemizwelo kwaye, kwiimeko ezinqabileyo, kukhokelela kwi-psychosis.
> Imithombo:
> I-Govoni, M .; Bortoluzzi, A .; Padovan, M .; okqhubekayo. "Uxilongo kunye noLawulo lwezonyango ze-Neuropsychiatric Shows of Lupus." Umbhalo we-Autoimmunity . 2016; 74: 41-72.
> Ho, R .; Thiaghu, C .; Ong, H .; okqhubekayo. "I-Meta-Analysis ye-Serum ne-Cerebrospinal Fluid Autoantibodies kwi-Neuropsychiatric Systemic Lupus Erythematosus." I ziPhulo zeMoto . 2016; 15 (2): 124-38.
> Magro-Checa, C .; Zirkzee, E .; Huizinga, T .; kunye ne-Steup-Beekman, G. "Ulawulo lwe-Neuropsychiatric Systemic Lupus Erythematosus: Iindlela ezikhoyo kunye neemeko ezizayo." Zi yobisi . 2016; 76 (4): 459-83.
> Shimizu, Y; Yasuda, S; Kako, Y; okqhubekayo. Ukubonakaliswa kwe-Post-Steroid Neuropsychiatric Ukubonakaliswa kubaluleke ngokuphindaphindiweyo kwi-SLE kuthelekiswa nezinye izifo eziziMzimba eziMzimbeni eziPhezulu nokuZilungela okuNgcono. Ukuqhathaniswa neDe Novo Neuropsychiatric SLE. " I ziPhulo zeMoto . 2016. 15 (8): 786-94.
> Tay, S. kunye noMak, A. "Ukuxilonga nokunika iIndeuropsychiatric Events kwi-Systemic Lupus Erythematosus: Ixesha lokukhupha i-Gordian Knot?" Rheumatology (Oxford) . Oktobha 15, 2016 (i-Epub phambi kokuprintwa).