Ulwaphulo-mthetho oPhezulu oPhezulu oPhezulu oPhezulu oPhezulu
Enye yeendlela utywala onokuyichaphazela ngayo ingqondo kukulimaza ukusebenza kwe- serotonin , ikhemikhali echaphazela umoya, ukulala, ukutya, umgangatho wokushisa, kunye nomoya.
Ngenxa yoko, abantu abajamelana nokuxhomekeka kotywala bavame ukubika iingxaki ngokuxinezeleka nokuxhalabisa. Abanikezeli beenkonzo zabo zononophelo baya kubonisa ukuba i-serotonin i-reuptake inhibitors ekhethekileyo yokubanceda bahlale benqanaba eliphezulu le-serotonin.
"I- SSRI yinkalo echazwe kakhulu kunabo bonke abachasayo," watsho uWilliam Dundon, uphando lophando oluphezulu kwisebe leengqondo kwiYunivesithi yasePennsylvania School of Medicine. "Umsebenzi we-SSRIs ngokuchaphazela inqanaba le-serotonin kwingqondo nakwezinye indawo emzimbeni. Echotsheni, i-serotonin icingelwa ukuba ifuthe imvakalelo, iimvakalelo, ukulala, ukutya, kunye nommiselo wokushisa."
Uphando lufumene, nangona kunjalo, ii-SSRI-ezifana ne-sertraline ( Zoloft ) -ngabasebenzi kakuhle kotywala.
I-Zoloft Ayisebenzeli Bonke Utywala
Ukucacisa ukuba kutheni ii-SSRI zinceda ezinye izigulane ngokusetyenziswa kakubi kotywala kwaye kungekhona abanye, uDundon kunye noogxa bavavanya iindidi ezibini zotywala ezichazwe nguTomas Babor weYunivesithi yaseConnecticut.
I-Babor yahlula abantu abaneengxaki zotywala kwiibini ezimbini, Uhlobo lwe-A kunye nohlobo B. Uhlobo lwe-A Utywala olusisiseko sendawo kwaye luyabonakala kamva ebomini, ngelixa uhlobo lwe-B oludakayo lugxininiso lwe-genetics luvela kwiminyaka yobomi.
Uhlobo B Utywala luyingozi kakhulu
Ngokutsho kophando lukaBabor, utywala obuthile B luhlala luba nefuthe elibi ngaphezu kohlobo lwe-alcoholism. Ngokuqhelekileyo, uhlobo lwe-B olutywala lunobungozi obunzima nangaphezulu kunokuba luhlobo lwe-alcoholism.
Ngethuba lokufunda, abatywala abangama-100 banikezwa iikhosi ezintathu zenyanga ye-sertraline (200 mg / ngosuku) okanye iipsulules ze-placebo kunye nonyango oluthile olusekelwe kwi-Alcoholics.
Uhlobo lwe-A A utywala kunye no-45 oTywala B batyhutyana nabo batyhutyana nabo malunga nokusetyenziswa kotywala.
UZoloft Unceda Uhlobo lwe-Alcoholics
Abaphandi baqhathanisa ukusetyenziswa kotywala kwinyanga ezintandathu emva kokunyanga kotywala kwinyanga yokugqibela yonyango. Ucwaningo lukaDundon lufumene ukuba uhlobo lwe-alcohol A lube nolululo olungcono kunyango kwiZoloft kunokuba zenziwe ngotywala.
Ngeenyanga ezintandathu zilandelayo unyango, Thayipha i-A ezidakwayo eziphathwe ngeZoloft zigcinwe zizuzo zabo, ngelixa utywala lweBlue B aluzange.
Ukugcina iziphumo ezintle
Ngokukodwa, uphando lweDundon lufumene:
- Thayipha i- alcoholics ezathatha uZoloft zigcinwe, ubuncinane ubuncinane inyanga ezintandathu emva kokuba unyango luphelile, iziphumo ezilungileyo ezifunyenweyo ngexesha lotyando
- Uhlobo oluthile lwezilwanyana eziphathekayo eziphathwe kunye noZoloft zaqhubeka zingabonakali nzuzo ze-pharmacotherapeutic ngexesha leenyanga ezintandathu emva kokunyanga.
- Ukusetyenziswa kotywala B, utywala obukhulu kunene ukwanda ngeenyanga ezintandathu emva kokunyanga noZoloft.
I-SSRI ayifanelekanga kuhlobo lwe-B
"Kubonakala ngathi siye safumanisa iqela lala manxila, Uhlobo lwe-As, owamkela kakuhle kwi-sertraline ngexesha lotyando kwaye agcinwe ukuzuza kwabo ngaphezu kweenyanga ezintandathu emva kokupheliswa," kutsho uDundon.
"Nangona kunjalo, kukho elinye iqela, uhlobo lwe-B, apho ii-SSRI ezingenako ukufaneleka. Le ngqutyana ibonakala igcina inzuzo yabo kwi-AA-based treatment kuphela xa bengayitholanga i-sertraline," esho.
Isizathu sokuba abaphandi bahlolisise iibini ezimbini zezobisi zibangelwa uphando oludlulileyo olucebise ukuba kukho ukungafani kwi-serotonin metabolism phakathi kwamaqela amabini. Uhlobo lwezilwelo zotywala lufunyenwe ukuba lunokungaqhelekanga kwi-serotonin metabolism, ekufundweni kwangaphambili, yaye bekucingelwa ukuba iqela liya kuba likhulu ukuphendula kwi-Zoloft unyango. Nangona kunjalo, izidakamizwa zohlobo lwe-B zenza okubi ngakumbi kwi-SSRI unyango kunye neenyanga ezintandathu, emva kwexesha lokunyanga.
Iingxaki zoLwaphulo loTywala
Abaphengululi baphetha ukuba banako ukufumanisa ukuba izidakamizwa ezingena kunyango zihlobo lwe-A okanye uhlobo B lunokuba luncedo ekuphuhliseni isicwangciso sonyango.
"Ndicinga ukuba isifundo sethu sichaza ngokucacileyo ukuba kunokuba neendlela zokwenza utywala kunye neengqungquthela ezahlukeneyo zotywala zingaphendula ngendlela eyahlukileyo," kusho uDundon. "Izicwangciso ezininzi zokucwangciswa ziye zacetyiswa ukuba zihluke iintlobo zotywala. Isifundo sethu sisekela ukusetyenziswa kohlobo lweBabor Type A kunye nohlobo lweB.
UFundo luqinisekisa ubungqina beBabor A no-B oTywala
Uphando olutshanje yi-Public Health Institute kunye neYunivesithi yaseCalifornia, iSan Francisco esebenzisa idatha evela kwi-National Epidemiologic Survey kwi-Alcohol kunye neemeko ezihambelanayo ziqinisekisile ukuba utywala lwe-A kunye nohlobo lwe-B lukho ubomi boqobo.
Uphononongo lufumene ukuba izidakamizwa zohlobo lwe-B ebantwini bonke, xa kuthelekiswa nohlobo lwe-As, zazinzulu kakhulu kunye noxinzelelo oluninzi lwezonyango, iingqondo, kunye nempilo yengxaki.
Uhlobo lwe-B olunxilisayo lwaba ziphindwe kabini ukuba lube ngumxhasi otywala emva kweminyaka emithathu kwaye mhlawumbi banokuba baphuze kakhulu kunye nezixhomekeke kwiziyobisi.
Imithombo
- Babor, et al. (2006). "Iindidi zotywala: ngokufanayo kunye nokuqikelela kwangaphambili kwezicwangciso ezithile eziqhelekileyo." Umlutha.
- Dundon, W. et al. (2004). Iziphumo zonyango ngohlobo lwe-A kunye no-B Ukuxhomekeka kwe-Alcohol 6 Inyanga Emva kwe-Pharototherapy Pharmacotherapy. Utywala: Uphando lwezonyango kunye noPhando .
- UTam, TW, no-al. (2014). "Ukusetyenziswa kohlobo lwe-A / B ukuxhomekeka kotywala kubantu bonke." Ukuxhomekeka kweziyobisi kunye noTywala.