Izizathu, ukuqaphela kunye unyango
I-Serotonin Syndrome yimeko esongela ubomi obangelwa yimilinganiselo ephezulu ye- serotonin kwinkqubo yomntu. Le meko ingeniswa ngokusetyenziswa kweziyobisi ezinjenge-serotonergic, ezibandakanya iintlobo ezininzi ze-anti-depressants ezifana ne- SSRIs (i-serotonin sele i-reuptake inhibitors) ekhethekileyo njenge- Paxil ne- Celexa , i- tricyclic njenge-amitriptyline kunye ne-trimipramine, kunye nee- MAOI (i-monoamine oxidase inhibitors) njenge-Nardil kunye neParnate.
Ezinye izinto ezinokuba negalelo kwi-serotonin syndrome ziquka i -st John's wort , cocaine, i-tryptophan, i-lithium, i-amphetamines, i-ecstasy, ne-LSD.
Ukongezelela, ezinye iziyobisi ezingekho ezingqondweni zingathintela inqanaba le-serotonin kwigazi. Ngenxa yoko, kubalulekile ukuba bonke oogqirha bakho abayalela ukuba amayeza ahlale esazi onke amayeza kunye nezongezelelo ozenzayo njengamanje.
Zonke ezi ziyeza kunye nezinto zichaphazela i- neurotransmitter serotonin ngandlela-thile. Ezinye zivimbela i-nerp receptors; i-block reuptake ; abanye bayanciphisa ukuphahlaka kwe-serotonin; abanye bakhulisa ukukhululwa kwe-serotonin (umzekelo, bona iMirrugs kunye ne-BP: i-Ecstasy ). Amanye amabhunga abantu aqhelekile ngokwemvelo kunokuba avame ukuhlaziya i-serotonin. U-Nolan no-Scoggin babike ukuba izigulane ezinezifo zesifo se-vascular zisengozini enkulu ye-serotonin syndrome. (Jonga i- Messenger yeBrain ngencazelo elula yendlela indlela eminye yale mi sebenzi isebenza ngayo.)
Phantse zonke izidandlululo ziqulethe ukuba izigulana kufuneka zilinde ubuncinane iiveki ezimbini (ngamanye amaxesha ngaphezulu) phakathi kokutshintsha phakathi kwezilwanyana ze-MAOI kunye nolunye uhlobo lwe-anti-depressant (nakwezinye izikhokelo). Esinye sezizathu eziphambili zezi nengozi yokuba zonke iintlobo zamachiza kwinkqubo yomntu zingakhokelela kwi-serotonin syndrome.
Iprozac (i-fluoxetine) ngokukhethekileyo ithatha iiveki ezimbalwa ukuba ikhutshwe ngaphandle komzimba.
Iimpawu
Izimpawu eziqhelekileyo ze-serotonin syndrome ziquka:
- Ukuhamba ngokukhawuleza okanye ukunyakaza okufana nokuhamba
- Ukuhluthwa okanye ukubola
- Ukuphamba okufutshane okanye okukhawulezayo
- Fever
- Intloko
- Ukuxhalabisa
- Ukuqina komzimba
- Ukudideka
- Ukungabi naso
- Ukukhupha
- Ukugubha
- Ukungasebenzi ngokufanelekileyo
- Ukuphefumula ngokukhawuleza
- Intliziyo engavumelekanga
- Igazi elonyukayo
- Ukukhupha
Kukhona enye ingxaki ephathelene neziyobisi, i- neuroleptic malignant syndrome (i-NMS), enezinye iimpawu ezifana ne-serotonin syndrome. Xa oogqirha bafumanisa isigulane esibonisa le mpawu, kubalulekile ukuba bayazi kangangoko kunokwenzeka malunga nomlando weyeza. Oku kungenxa yokuba i-serotonin syndrome ngokuqhelekileyo ifika ngokukhawuleza emva kokuba iqalise iyeza zokuqala, ngelixa i-NMS ithatha ngokuqhelekileyo malunga neenyanga ukubonisa.
Unyango
Umgca wokuqala wonyango ukuyeka zonke iziyobisi ezichaphazela i-serotonin. I-Benzodiazepines inokuba luncedo ekunciphiseni iimpawu ze-muscular, kwaye unyango olunokuxhasa lunokuba luyimfuneko kwiimeko ezifana nokuphefumula okuphefumulayo. Iziyobisi ezenza ngqo ngokumelene ne-serotonin zinokuba luncedo.
Kwiimeko ezininzi, iimpawu zihamba ngokukhawuleza xa oko kwenziwa kwaye isiguli siyifumana ngokupheleleyo.
Nangona kunjalo, kufuneka kugxininiswe ukuba i-serotonin syndrome ingaba yingozi, ngoko kubalulekile ukufuna uncedo ngokukhawuleza ukuba wena okanye othandekayo unokufumana nayiphi na impawu ekhankanyiweyo emva nje kokuqala ukuxhatshazwa kwintsholongwane okanye ukutshintsha ukusuka kwelinye ukuya kwelinye.
I-SSRI yokuLawula iSyndrome
Kufuneka kuqatshelwe ukuba ezinye zeempawu ezifanayo ezibhalwe apha ngasentla ziyakwenzeka xa umntu engayeki ngokukhawuleza ukuthatha i-anti-depressant okanye ayifake ngokukhawuleza ngokukhawuleza. Ukuxhalazela, iintloko, ukukhathazeka okufana nokutshatyalaliswa, ukulungelelanisa ukulungelelanisa, ukunyamezela nokugxininiswa kwamanye amazwe ziimpawu eziqhelekileyo kuzo zombini.
Bona iSyri Discontinuation Syndrome ngokujonga ngokujulile kuloo meko.
> Iingcaciso:
> Nolan, S., kunye no-Scoggin, JA "I-Serotonin Syndrome: Ukwazisa kunye noLawulo." US Pharmacist 23: 2. http://www.uspharmacist.com/oldformat.asp?url=newlook/files/feat/acf2fa6.htm.
> Gomersall, C. "iSerotonin Syndrome." Julayi 2006
> HealthyPlace.com. "Monoamine > Oxydase > Inhibitors (MAOIs)."