Iingxaki kunye nokuthintela ukuxhatshazwa
I-serotonin reuptake inhibitors (SSRIs) ekhethiweyo iyinkqubo yesicatshulwa esisetyenziswa ngokuphatha ukudandatheka . Amachiza anceda ukuqhelanisa ubuchopho ukusebenza kubantu abaneengxaki ezithile zengqondo ngokunyusa inani le- serotonin ebuchosheni. I-Serotonin luhlobo lweekhemikhali, olubizwa ngokuba yi-neurotransmitter, enenjongo yokuhambisa imiyalezo kunye nakwiiseli zengqondo. Ngokwenza njalo, i-chemistry engqondweni ingakwazi ukulawulwa ngendlela ephucula ukuxinezeleka komntu okanye ukukhathazeka .
Nangona kunjalo, xa unyango lwe-SSRI lugqityiwe, abanye abantu bafumana uhlobo lokuhoxiswa kwe-SSRI yokuyeka ukugula. Ngokuqhelekileyo kubonakala xa unyango lugqitywa ngokukhawuleza kwaye lunokubonakalisa ngeempawu ezibonakala zifana nokudakumba nokuxhalabisa. Ngenxa yoko, abantu abahlala bekholelwa ukuba "baphinda" kwaye bacela ukuba babuyiselwe kwi-SSRI.
Ukuqonda ukuba kutheni iSyri Discontinuation Syndrome ivela
Iziyobisi ze-SSRI ezisetyenziselwa ukunyanga izifo zengqondo zineendlela ezifanayo zesenzo kodwa iinqununu ezihlukeneyo zesigidi sempilo. Ukusetyenziswa kweziyobisi isigamu-bomi lixesha lokuchaza indlela i-molecule ye-drug esebenza ngayo ixesha elide lihlala egazini ngaphambi kokuba ikhutshwe emzimbeni.
Ukuba isilwanyana sinomlinganiselo omncinci wobomi, kuya kufuna ukuba i-dosing iqhubekele rhoqo ukuze igcine ingxube efanelekileyo egazini. Ukuba unesiqingatha-sobomi obude, luya kuhlala luhlala ixesha elide kwaye lube luncinci ukuya phezulu.
I-SSRI amayeza asetyenziswe ukuphathwa kwengcinezelo iquka:
- Prozac (i-fluoxetine)
- Zoloft (sertraline)
- Paxil (paroxetine)
- Celexa (citalopram)
- Lexapro (escitalopram)
Kule ndawo, i-Prozac inexesha elide elide lobomi kwaye, xa limile, liya kuhamba ngokukhawuleza kwigazi. Abanye, ngokuphambene, banemizuzu emfutshane-bomi kwaye, xa beka, baya kuphazamiseka ngokukhawuleza. Xa kwenzeka le nto, umntu unokufumana iimpawu eziphazamisayo kunye neempawu zokugxotha.
Indlela i-SSRIs Effect Changes in Brain
Kodwa isicatshulwa sempilo esisigxina sinxalenye yeso sizathu saloo mpawu. Xa zisetyenziselwa ixesha elide, ii-SSRI zinokutshintsha utshintsho kwingqondo ekhokelela ekutholeni amancinci omncinci kunye namancinci. Oku kubangelwe, kwinqanaba, ukuba i-SSRI ibangela ukunyuka kwe-serotonin kwingqondo.
Xa oko kwenzeka, ingqondo iya "phantsi-lawula" inani labalamkeli ekuphenduleni kwindleko eyandisiweyo ye-serotonin. Yenza isenzo sokulinganisela okwenyama sokuthintela ukugqithiswa kweeseli zengqondo.
Xa unyango ekugqibeleni lugqityiwe, kuya kubakho amancinci ambalwa ngaphezu kokuqala kunye nokusilela kwexesha elifutshane lomsebenzi we-serotonin. Umzimba uya kulungisa ngoku, kodwa, de kube yenze, umntu unokudlula ixesha lokulungisa kuze kube yinkqubo kwakhona kwakhona.
Iimpawu zeSyri Discontinuation Syndrome
Iimpawu eziqhelekileyo ze-SSRI yokuyeka isifo zichazwa nje ngokuba zifana nomkhuhlane okanye uzive ngathi ukubuyela ngokukhawuleza kokuxhalaba okanye ukuxinezeleka. Ziquka:
- Utywala
- Vertigo
- Lightheadedness
- Unzima ukuhamba
- Isihlunu / ukuhlanza
- Ukukhathala
- Ukutshatyalaliswa
- Intloko
- Ukungabikho
- Uhudo
- Ubuhlungu besisu
- IChills
- Ukuzivocavosa okunjengezinto
- I-Pherehesia (ukutshisa, ukutshitshisa, okanye ukunyuselwa kwesikhumba)
- Ukuphazamiseka kokubonakalayo
- Uxinzelelo oluthathaka
- Amaphupha angafanelanga
- Ukuxhomekeka kwamanye amazwe (i-out-of-body-experience)
- Iingcamango zokuzibulala
- Psychosis
- I-Catatonia (imeko yokungaphenduli)
Xa iimpawu zingenakunqikaza, azinqabile kakhulu. Uninzi lwawo kuphela lufumana iindlela ezincinci ukuya kwiimodareyithithi zokuyeka.
Ukuthintela iSyri Discontinuation Syndrome
Bonke baxelelwe, malunga neepesenti ezingama-20 zabantu abakwiPaxil, i-Zoloft, iCelexa, okanye i-Lexapro baya kufumana umlinganiselo othile wokuhoxiswa emva kokupheliswa kwonyango. Uninzi lokugqibela ukusuka kwenye ukuya kwiiveki ezisixhenxe. Kwabo bebehlala kwi-SSRI iminyaka emininzi, iimpawu zingase ziqhubeke ixesha elide.
Ukuze ugweme umngcipheko we-SSRI yokuyeka ukugula, xela nodokotela wakho malunga nokuncothula kwi -drug slowly. Ukuthetha ngokuqhelekileyo, ukuba unyango luye lugqiba ngaphantsi kweeveki ezisibhozo, ukugqithisa ngaphezulu kweyure ukuya kwiiveki ezimbini kubonakala kunengqiqo. Emva kweenyanga ezintandathu ukuya kwisibhozo unyango, unokufuna ukuba uphume kwiikhosi ezintandathu ukuya kweebhozo.
Kodwa thabatha icebiso lethu: ungazami ukwenza oku ngokwakho. Sebenza kunye nogqirha wakho, ngubani oza kuqonda kakuhle iimingcipheko kunye nezingozi ezinokuthi ziphi na iziyobisi ozithathayo.
Imithombo:
> Fava, G .; Gatti, A; Belaise, C; okqhubekayo. Izimpawu zokuLawula emva kweSerotonin ekhethiweyo yokubuyiswa kwe-Inhibitor: UkuHlola okuHlolo. " I-Psychotherapy ne-Psychosomatics . 2015; 84 (2): 72-81.
> Harvey, B. kunye no-Slabbert, F. "Iingcaciso ezintsha kwi-Anti-depressant Discontinuation Syndrome." Psychopharmacology . 2014; 29 (6): 503-16.