I-Scarce Science nge-This Calcium Channel Blocker
I-Verapamil, uhlobo lwe-blocker ye-calcium yesigcawu, yafundiswa kwiminyaka edlulileyo njengonyango lweengqungquthela zamadoda kubantu abaneengxaki zokuguquka kwe-bipolar. Oko kuthetha, inzululwazi yolwazi emva kwayo ayinanto kwaye iphikisana, oku kuthetha ukuba uphando oluthile lufumene inzuzo kwaye abanye abangekho. Kungakhathaliseki ukuba, akuyona impawu eqhelekileyo okanye eqhelekileyo esetyenziswe ngabagula ngengqondo ekuphatheni i- bipolar disorder .
Makhe sihlolisise imbali yenzululwazi emva kokusebenzisa i-verapamil kunye nezinye izithinteli zesitishi se-calcium kwi-bipolar disorder.
Ziziphi iCalcium Channel Blockers?
Iimpawu zecala ye-calcium zithintela ukunyakaza kwe-calcium kwiiseli zentliziyo kunye nemithambo yegazi, ukuphucula imithana yegazi nokunyusa ukunikezelwa kwegazi kunye ne-oksijini entliziyweni. Ngokuqhelekileyo zisetyenziselwa ukunyanga uxinzelelo lwegazi oluphezulu, i-arrhythmia (iintliziyo ezingapheliyo) kunye ne-angina pectoris (intlungu yesifuba).
Iinqununu eziphambili ze-calcium ezithintela izixhobo eziye zahlolwa njengezinto ezinokuthi zithinteke ngenxa yengxaki yokuguquka kwengqondo, ngokukodwa ngeengqungquthela zomntu ziquka:
- I-Verapamil - amagama e-brand Calan, i-Isoptin SR
- I-Nimodipine - igama le-brand ye-Nimotop
- I-Diltiazem - amagama e-brand Cardizem, i-Cartia XT, i-Dilacor XR, iTiazac
IVerapamil
Ngokubhekiselele kwinto enokuba luncedo, olunye u-2002 kwi- Biological Psychiatry lihlolisise abafazi abalishumi elinama-11 abaneemania okanye iimpawu ezixutywayo zokudandatheka kunye ne-mania.
Kula mabhinqa aba-11, aba-9 kubo babonisa impendulo efanelekileyo okanye uphuculo kwimania yabo emva kokuba baphathwe nge-verapamil.
Ngophando luka-2008 kwi- Bipolar Disorders, i- verapamil yodwa ayizange iphucule iziqwenga zomntu, kodwa xa idibene ne-lithium, yenze. Oko kushiwo, isifundo sasisincinane, kunye nezigulane ezili-10 kuphela ezithatha inhlanganisela ye-verapamil kunye ne-lithium.
Umbhali waqaphela kwakhona ukuba nayiphi na umntu ethatha inhlanganisela ye-verapamil kunye ne-lithium kufuneka ihlolwe ngokukhawuleza, njengoko kunokwenzeka ukuba iziphumo ezibi kakhulu zifana nezi:
- ukunyuka kwimiba emibi ye-lithium
- i-choreoathetosis - ukunyanzelisa ngokungenayo
- ukukhawuleza kwenhliziyo kunye nokuhlaselwa kwentliziyo
- iingxaki ngokusebenzisana
Nimodipine
Olunye uvavanyo luka-2002 kwi- American Journal ye-Obstetrics ne-Gynecology luchaze ngokusetyenziswa kakuhle kwe-nimodipine kwindoda ekhulelwe. Akazange akwazi ukunyamezela ukuzinza kwesimo semveli, i-lithium.
Kwakhona, ngokutsho kwexesha elidala kwi- Bipolar Disorders , i-nimodipine inokuba luncedo kubantu abaneentsholongwane ze-bipolar abangaphenduliyo kwiimithi zendabuko, ngakumbi abo bahamba ngeendlela ezinokukhawuleza ngokukhawuleza.
Diltiazem
Kwisifundo esincinci se-2000 kwi- Journal of Psychiatry ne-Neuroscience, yezigulane ezisibhozo ezineengxaki ezingaphephekiyo ezibangelwa yi-bipolar disorder, kwakukho ukuhla kwezinto zomzimba kunye nokudandatheka kweempawu emva kokuthatha i-diltiazem. Oko kushiwo, kukho iingxaki malunga nokuyila kovavanyo. Ngokomzekelo, izigulana zithatha amanye amayeza ngaphandle kwe diltiazem, kwaye yayincinci.
Kuthetha Kanjani Oku Konke?
Kubalulekile ukuqonda ukuba i-blockers ye-calcium yee-blockers ayifani imithi efana ne-mania-njengokuba kuboniswe ukuba kukho izifundo ezimbalwa kuzo.
Ngaloo nto, akucaci ngeli xesha ukuba yintoni indima yexesha elizayo ye-block calcium block blockers eya kuba kunyango lwe-mania ye-bipolar disorder. Kungenzeka ukuba isetyenziselwa ukudibanisa nezinye izimo zengqondo xa umntu engaphenduli kwimeko yokuzinza yedwa okanye enye inhlanganisela yemilisi.
Imithombo:
UDuvsvsky SL, iiFranks RD, u-Allen S, no-Murphy J. Psychiatry Res. Ngo-1986 uAgasti; 18 (4): 309-20.
I-Goodnick PJ Ukusetyenziswa kwe-nimodipine kunyango lweengxaki zengqondo. I-Bipolar Disord. 2000 Septemba; 2 (3 Pt 1): 165-73.
Mallinger AG et al. I-Verapamil augmentatin yonyango lwe-lithium iphucula iziphumo e-mania ezingaphenduliyo kwi-lithium yedwa: ukufunyaniswa kwangaphambili kunye nengxoxo yeendlela zokwelapha. I-Bipolar Disord . 2008 Dec; 10 (8): 856-66.
Silverstone PH & L. Birkett. I-Diltiazem njengonyango lokunyuka kwamayeza kwizigulana ezineengxaki ezingagwenyanga bipolar disorder: i-retrospective study. J Psychiatry Neurosci. Ngo-2000 ngoMeyi; 25 (3): 276-80.
Wisner KL et al. I-Verapamil unyango kwabasetyhini abaneengxaki zokugula ngengqondo. Biol Psychiatry. 2002 Meyi 1; 51 (9): 745-52.
Yingling i-DR, i-Utter G, i-Vengalil S, kunye ne-Mason B. i-block ye-calcium, i-nimodipine, yokunyangwa kwe-bipolar disorder ngexesha lokukhulelwa. IJ Obstet Gynecol . 2002 Dec; 187 (6): 1711-2.