Amanqanaba e-Norepinephrin eyandayo kwingqondo anokuphucula amandla
I-Norepinephrine, eyaziwa nangokuthi i-noradrenaline, ibini ihomoni kunye ne-brain neurotransmitter, okanye imichiza. Kugcinwa kakhulu kwi-neurons (iisensi ze-nervous) zesistim se-nervous sympathetic system (i-nervous system) kunye nemali encinci kwaye igcinwe kwiisisindo eziqhelekileyo, ezibekwe phezulu kwezintso zakho.
Njengehommone, i-norepinephrine ikhutshelwe kwigazi ngeempawu ze-adrenal kwaye isebenza kunye ne-adrenaline (eyaziwayo njenge-epinephrin) ukunika umzimba amandla angaphandle ngokukhawuleza ngexesha loxinzelelo, eyaziwa ngokuba yi-"ukulwa okanye indiza".
Njenge- neurotransmitter , i-norepinephrine idlula impembelelo yesibindi ukusuka kwelinye i-neuron ukuya kwelinye elilandelayo.
I-Serotonin-Norepinephrine Reuptake Inhibitors (i-SNRIs)
Amachiza avimbela ukuhlaziywa kwe-norepinephrin kunye ne- serotonin (enye enye i-neurotransmitter) ibizwa ngokuthi i- serotonin-norepinephrine reuptake inhibitors (i-SNRIs). Ngokuvimbela ukubuyiswa kwakhona kwezi zimbini ze-neurotransmitters, ii-SNRIs zibalulekile ukwandisa amanqanaba e-norepinephrine kunye ne-serotonin kwingqondo. I-Serotonin yenza umntu azive kakuhle kwaye i-norepinephrine ithuthukisa amandla kunye nokunyamekela.
I-SNRIs ifumaneke ukuba isebenze ekuphatheni iziphazamiso zengqondo ezifana nokudandatheka, ukukhubazeka kwe-bipolar, kunye neengxaki zokuxhalabisa. I-SNRI ngamanye amaxesha imiselwe ukuba ibuhlungu obungapheliyo kunye ne-fibromyalgia.
I-SNRIs yokuPhatha izifo zoMoya
I-SNRI evunyelwe ukusetyenziswa ekudakaleni okukhulu kubandakanya i- Cymbalta (duloxetine), i- Effexor (venlafaxine) ne- Pristiq (desvenlafaxine), kodwa ezinye zivunyiwe ezinye izifo ngokunjalo.
Nangona kungekho zixinzelelo, ezibandakanya i-SNRIs, ziye zavunywa yi-US Food and Drug Administration (FDA) ukunyangwa kwengxaki ye-bipolar, ngamanye amaxesha anikwe njengenxalenye yesicwangciso sonyango.
Iziphumo eziqhelekileyo ze-SNRIs
I-SNRI inokunyusa uxinzelelo lwegazi lomntu, ngoko ugqirha wakho angathanda ukubeka ingqalelo uxinzelelo lwegazi xa echaza enye.
Ukuba sele unzima ukulawula uxinzelelo lwegazi, i-SNRI ingabi yinto enhle kuwe.
Ezi mpawu zihlala zihamba emva kweeveki ezimbalwa, kodwa ukuba azinako okanye zixhalabisa, qiniseka ukuba uqhagamshelane nogqirha wakho. Ezinye iziphumo eziqhelekileyo zeSNRI ziquka:
- Utywala
- Umlomo omile
- Ukuphosa ngaphezu kwexesha eliqhelekileyo
- Isisu esimoshakele
- Ukukhathala
- Intloko
- Ukulahlekelwa ngumdla wakho
- Ukutyunjwa
- Ubunzima bezesondo
- Ukuxhalabisa
- Unzima ukuchama
Intsapho yeSerotonin-Norepinephrine Reuptake Inhibitors
I-SNRI nganye yeyona nto ihluke ngokwemichiza kwabanye.
Effexor (Venlafaxine)
I-Exexor yayiyi-SNRI yokuqala eya kuvunyelwa e-United States ngo-1993. Yavunywe yi-FDA yokudandatheka, ukuphazamiseka kwesifo, i-phobia yezenhlalakahle, kunye neengxaki ze-anxiety (GAD). I-Exexor inqanda ukubuyiswa kwakhona kwe-serotonin ngokugqithiseleyo kunokuba i-norepinephrine.
I-Cymbalta (i-Duloxetine)
Ngo-2004, i-Cymbalta yayisibini ye-SNRI ukuba ivunyiwe e-United States. yendlela esebenza ngayo, inenombolo ephezulu ye-FDA-avunyelwe ukunyanga izifo, kubandakanywa ne-diabetis peripheral neuropathy, ukuxinezeleka, ingxaki yokukhathazeka jikelele, i-fibromyalgia, i-osteoarthritis, kunye neentlungu zentlungu. Njengo-Exexor, iCymbalta iyakuthintela ukubuyiselwa kwakhona kwe-serotonin ngaphezu kwe-norepinephrine, kodwa kwinqanaba eliphantsi.
Pristiq (Desvenlafaxine)
Pristiq, i-SNRI yesithathu iya kuvunywa. Kuye kwavunyelwa kuphela ukuphatha ukudakumba okukhulu kunje. I-Chemically, uPristiq isebenza ngokufanayo kwiCymbalta.
Savella (Milnacipran)
Le yowesine i-SNRI yokuvunyelwa e-US ukuphatha i-fibromyalgia. I-Savella isebenza ngokuthintela ukubuyiswa kwakhona kwe-serotonin kunye ne-norepinephrine ngokulinganayo kwaye inokuthi iyakuthandana ne-norepinephrine, ngokweminye imithombo.
Fetzima (Levomilnacipran)
Ilungu elisandul 'ukutshatyalaliswa kwintsapho ye-SNRI, i-Fetzima ivunyiwe yi-FDA ngo-2013 kwaye iphinde ivunyiwe yi-FDA yokuphatha uxinzelelo.
I-Fetzima ivimbela i-norepinephrine kwakhona ukuphindaphinda kabini njenge-serotonin yokubuyisela kwakhona, eyenza ibe yodwa phakathi kwe-SNRIs.
> Imithombo:
> Moret C, uBriley M. (2011). Ukubaluleka kwe-norepinephrin ekudakaleni. Neuropsychiatr Dis Treat. 2011; 7 (iSiza 1): 9-13.
> Sansone, RA, Sansone, LA (2014). I-Serotonin Norepinephrine I-Reuptake Inhibitors: Ukuthelekiswa kwe-Pharmacological. Ukulungiswa kweeNzululwazi zeCliniki . 11 (3-4): 37-42.