Ulwazi lwe-FDA kwiMiphumo engasetyenziswayo kunye neMilinganiselo
I-Nefazodone i- anti - depressant engabancedisa abo abangazange baphendule kakuhle kwezinye i-antidepressants. Iyakhathaza ingozi engabonakaliyo, kodwa eyingozi, yingozi yesibindi, kufuneka isetyenziswe ngokucophelela.
Sibanzi
Makhe sifunde kabanzi malunga nefazodone, kubandakanywa izibhengezo zebhokisi ezimnyama, iziphumo ezibi, kunye namayeza ngokusekelwe kwingcaciso evela kwi-FDA.
Kubalulekile ukuba uqaphele ukuba ukuthengiswa kweSerone, imichiza ye-brand ye-Nefazodone, inqatshelwe ngo-2003 e-United States ngenxa yokungabonakali komonakalo omkhulu wesibindi.
Kodwa iifom ze-generic ze-nefazodone ziyafumaneka.
Isilumkiso sokungaphumeleli kwesibindi
Kwiimeko ezinqabileyo, abantu abathatha i-nefazodone baye bahluleka ukubulala. Ukuba ubona naziphi na iimpawu ezilandelayo, biza ugqirha wakho ngokukhawuleza:
- Ukuqhwala kwesikhumba okanye abamhlophe bamehlo (i-jaundice)
- Umchamo omnyama ongaqhelekanga
- Ukulahlekelwa kwesidlo esenza iintsuku eziliqela okanye ngaphezulu
- I sizathu
- Ubomi (isisu esisiswini) intlungu
- Ndiziva ndingavumi
Abantu ababenayo nayiphi na ingxaki yesibindi akufanele bathathe le mayeza.
Oogqirha baya kuhlola rhoqo iimvavanyo zegazi zesibindi ngelixa bathatha i-nefazodone.
Ukuzibulala Kwisibhozo seNtsundu
Njengabo bonke abaxinzelelekileyo, eUnited States, i-nefazodone ithatha isilumkiso somnyama ngokuphathelele ukuzibulala. Oogqirha bacacisa ukuba la mayeza ayacetyiswa ukuba ajonge ngokugqithiseleyo izigulane zabo ngenxa yokudakumba kwengcinezelo yabo okanye iingcinga zokuzibulala, ngokukodwa ekuqaleni kweyeza, okanye nayiphi na iinguqu kwiqondo.
Isistim
Ngokutsho kwe-FDA, umthamo owenzelwe ukuvelisa umthamo ngowama-200 mg / ngosuku kumanani amabini, ekuseni nakusihlwa. Isilinganiselo sinokunyuka kancinci, silinde imiphumo emibi ukuba ihlawule ngaphambi kokunyuka kwinqanaba elitsha. Kwizilingo zekliniki, ulwabiwo olusebenzayo lwama-300 ukuya ku-600 mg / ngosuku.
Olunye uphuculo, ngokukodwa kwixhala kunye nokulala (ukuba kukho), kufuneka ukuba ivezwe ngumguli kwisonto lokuqala okanye ezimbini. Kodwa unako iiveki ezimbalwa kwiinyanga ezimbalwa ukwenzela ukuba izibonelelo ezipheleleyo ze-nefazodone zifumaneke.
Ukusebenzisana kweziyobisi
Buza udokotela wakho ngaphambi kokuba uthathe i-nefazodone ukuba uthatha nawaphi na amayeza alandelayo, kuba ukusebenzisana okunzulu kwenzeka:
- I-Tegretol (i-carbamazepine) - isoloko ichazwe njengendlela yokuzinza kwe-bipolar disorder
- Hismanal (asestemizole) - imithi yonyango - ngoku ihoxiswa kwimarike
- I-Orap (i-pimozide) - imithi yokulwa ne-antipsychotic
- I-propulsid (cisapride) - unyango lwe-acid reflux
- Naliphi na i- MAOI edibeneyo
- I-Halcion (i-triazolam) -iyeza lokuxhalabisa
- Xanax (alprazolam) - unyango oluxhatshazayo
Vumela iiveki ezimbini phakathi kokumisa nayiphi na i-MAOI kwaye uqale nefazodone, kunye neveki enye phakathi kokuyeka i-nefazodone kunye nokuqala unyango kunye naluphi na i-MAOI.
Kukho ezinye iintlobo zokusebenzisana kweziyobisi kunye nefazodone, ngoko funda ulwazi lwesigulana ehamba nomyalelo wakho ngokupheleleyo. Yazisa ugqirha wakho ukuba ufumanisa nayiphi na ingxaki.
Kwakhona, umvelisi uncoma ukuba izigulane zixelele ugqirha ukuba ziyakhulelwa okanye ziceba ukukhulelwa ngexesha lonyango.
Izigulane kufuneka ziqhagamshelane noogqirha ukuba zibele.
Imiphumela
I-Nefazodone isebenza ngokuvimbela ukubuyiswa kwakhona kwe- serotonin kunye ne- norepinephrin , eziyizobisi zengqondo ezichaphazelekayo. Nangona kunjalo, ngokungafani nama-anti-depressants SSRI, i-nefazodone ehambelana nokufumana ubuncinci obuncinci kunye nemiphumo engaphantsi yobucala.
Ukongezelela, ukusetyenziswa kombiko we-mania / hypomania kunokunciphisa nge-nefazodone kunamanye ama-antidepressants kwizigulana ze-bipolar. Oko kuchazwa, enye ingozi ihleli, ngoko ke izigulane kufuneka zihlolwe ngugqirha wazo ekuqaleni kwe-mania okanye i-hypomania xa uthatha oku okanye naluphi na uxinzelelo.
Iziphumo eziqhelekileyo ezichaphazelekayo zibandakanya:
- kulala
- umlomo owomileyo
- isicaphulelo
- ukuqothulwa
- ubuthathaka
- ukungcola
- iingxaki nombono
- u bunzima
- kudideka
Ndingenza ntoni?
Ukuba ugqirha wakho ucinga nge-nefazodone yokudakumba kwakho, qiniseka ukuba ulandelelana naye.
Imithombo
I-Carvajal García-Pando A. I-hepatotoxicity enxulumene ne-anti-depressants entsha. J Clin Psychiatry . 2002 Feb; 63 (2): 135-7.
FDA. (2003). I-Serzone (nefazodonen hydrochloride).