Okufuneka Ukwazi Ngama-SSRI kunye namanye ama-Mood-Lifting Meds
Nsuku zonke, omnye kwabathathu baseMerika uthatha unyango lweengqondo, ngokuphathelele kwiphando le-2017 elipapashwe kwiNcwadi ye-American Medical Association (JAMA) . Iipesenti ezilishumi elinesibini zale mithi yonyango ziyi-antidepressants, imithi enokuthi ibe yindoda yokukhusela abantu abajongene neempawu zentsholongwane ephazamisayo-iimpawu ezibangelwa ukudabuka kunye nokulahlekelwa ngumdla kwizinto abaye babethanda ukuzenza kwiimvakalelo ezigqithiseleyo zokungancedi kwaye iingcinga zokuzibulala.
Xa ucinga malunga neengcinezelo zokudambisa, owokuqala onokuyifika entloko yakho yiProzac (i-fluoxetine). Kuseyona nto ingcono kakhulu kubantu abaninzi, kodwa ekubeni ivunyiwe yi-US Food and Drug Administration (FDA) ngo-1987, i-Prozac iye yahlanganiswa nezinye iintlobo zokuxhatshazwa. Ukuba ucinga ukuthatha i-anti-depressant, ukuqonda indlela abathandwa kakhulu abayisebenzayo banokukunceda wena kunye nogqirha wakho ugqibe ukuba yiyiphi enye into enokusebenza ngayo.
I-Serotonin Reuptake Inhibitors (i-SSRIs)
Iprozac ikwaseklasini yama-antidepressants ekuthiwa yi-serotonin e-reuptake inhibitors (SSRIs) ekhethekileyo. I-Serotonin yintsholongwane ekhoyo emanzini nasengqondweni. Ama-neurotransmitters ayenemichiza eya kunceda ukuthumela imiyalezo ukususela kumaphethelo omnyazi kumanye amathambo, okanye kumasipha okanye ezinye izakhiwo.
Kwiengqondo, amanqanaba aphantsi e-serotonin aye adibene nokuxinezeleka kunye nokuxhalaba kunye nokuphazamiseka kokuphazamiseka nokuziphatha okunyanzelekileyo. Amanqanaba aphantsi e-serotonin emanzini adibaniswe nesifo sengqondo sesifo, i-osteoporosis, kunye nezifo zentliziyo.
I-SSRI yenza oko kanye eli gama lichaza: Ziyakhusela ukubuyisela kwakhona (ukunyuka kwakhona ekugqibeleni kwemizwa) ye-serotonin, okwenza ezininzi zeekhemikhali zifumaneke. Ngamanye amagama, ii-SSRI zinciphisa uxinzelelo ngokuphakamisa amanqanaba aphantsi e-serotonin kwingqondo.
Iinqununu eziSithandathu ezidume kakhulu
Ngaphambi kwe-SSRIs, kwakukho iiklasi ezimbini eziphambili ze-antidepressants- monoamineoxidase inhibitors (MAOIs) kunye ne-tricyclics.
Zombini ezi ntlobo zonyango zibe nemiphumo engaphezulu kunezi-SSRI kwaye ziyingozi xa umntu ekhutshiswe ngengozi kakhulu, ngoko kulula ukubona ukuba kutheni kubekho ukwanda kweentlobo ze-SSRI zokukhetha.
Uninzi lwe-SSRI lufana kakhulu malunga nokusebenza kakuhle, nangona kukho ukungafani okucokisekileyo oku kunokukwenza ukuba kube lula ukuba kukhethwe kwelinye. Kuthatha ixesha elithile ukuba onke ama-SSRI akheke emzimbeni okwaneleyo ukuba abe nempembelelo kwiimpawu, nangona kunjalo, ngoko unako iiveki eziliqela okanye iinyanga zokuvavanya kunye nephutha ukufumana isilwanyana esithile kunye nomyinge oza kukukwenza kulungile.
Imiphumo emibi ye-SSRI eyahlukahlukileyo iyahlukahluka kakuhle, kodwa ngokubanzi, unokufumana nanoma yimaphi ambalwa aqhelekileyo kunye nabancinci besikhashana, njengentlanzi, isifo sohudo, intloko, isisu, umlomo owomileyo, ukuthuthumela, nokuthuthumela. Ngokubhekiselele kwimiphumo emibi yecala kunye neyingozi, abanye abantu bafumana isisindo emva kokuqala ukuthatha i-anti-depressant, nangona ngamanye amaxesha akusiyo izidakamizwa ngokwabo kodwa kulungele ukuthanda ukutya kunye nokuxabisa ngokutsha kokutya okubeka iipounds.
Abanye abantu bafumana ukuthatha i-anti-depressant kubeka i-damper kwimpilo yabo yesondo: Amadoda angaba neengxaki zokufumana ukulungiswa, umzekelo, kunye nabasetyhini banokuba nzima ukufikelela kwi-orgasm, ukuze kube lula ukubaluleka ukuba ubuhlobo obusondeleyo .
Abantu abathatha i-SSRI banokufumana ukuba izidakamizwa zibangela ukuba bazive bexakekile kwaye besaba; abanye abantu baneengcamango zokuzilimaza okanye ukuzibulala. Iintsholongwane zisengozini kakhulu kule nto kwaye kufuneka zijongwe ngokukhawuleza. Kubalulekile ukucima ukuxhatshazwa kancinci. Ukuba unokuyeka ngokukhawuleza ukuthabatha unokufumana iimpawu zokurhoxisa, ezifana nokuguquka kwemizwelo, utywala, iimpawu ezinjengomkhuhlane kunye neentloko.
- Prozac (i-fluoxetine) . Kwakhona, i-Prozac isesinye seSRRs ezithandwa kakhulu. Ngenye yezona kuphela ze-FDA ezivumile abantwana nabaselula ukuba basebenzise.
- Celexa (citalopram). Izifundo zibonisa ukuba uCelexa usebenza kunye namanye ama-SSRI kwaye unemiphumo emibi efanayo. Enye into ebalulekileyo ukwazi malunga nale ngxaki yokuxhatshazwa kukuba ukuthatha amanani aphezulu ahlanganiswe nenxaki yesantya esinqabileyo.
- Zoloft (sertraline) . I-Zoloft iphumelela kakhulu, nangona abanye abantu befumanisa ukuba kunezinye ii-SSRI zokubangela uhudo.
- Paxil (paroxetine) . Ungase ube nemiphumela emibi yezocansu xa ukhetha uPaxil ngaphezu kwamanye ama-antidepressants. Kudibaniswe nomngcipheko ophezulu wokukhupha.
- Lexapro (escitalopram) . Kanye kunye neProzac, iLexapro yenye ye-SSRI kuphela evunyiwe yi-FDA kubaselula ukuba basebenzise.
Ezinye izixinzelelo
Ezinye izidakamizwa eziqhelekileyo zivela kwiklasi yeziyobisi ezibizwa ngokuba yi- serotonin kunye ne-norepinephrine reuptake inhibitors (i-SNRIs). Ezi zivimbela ukubuyiswa kwakhona kwezi-neurotransmitter ezimbini: i-serotonin kunye ne-norepinephrin. Enye ye-SNRI eqhelekileyo ngokuqhelekileyo i- Effexor (venlafaxine) , esebenzayo njengenye i-antidepressants ekuphatheni i-MMD, kodwa inomlinganiselo ophezulu wokubangela isicupunu kunye nokuhlanza, kwaye inokunyusa uxinzelelo lwegazi kunye nentliziyo.
I-SNRI Cymbalta (i-duloxetine) nayo inokunyusa uxinzelelo lwegazi, kodwa ukukhathazeka okukhulu kwesi sigulo kukuba kwabanye abantu kunokukhokelela ekuphelelweni kwesibindi, ngoko ke ukuba unaluphi uhlobo lwesifo sesibindi kunokuthi kube yingozi kuwe. Kwakunjalo ukuba usela kakhulu utswala.
Kukho omnye oqhelekileyo ochazwe ngumntu ogxininisekile ongafanelanga naluphi uhlobo, u- Wellbutrin (bupropion) , osebenza ngokusebenza kwi-neurotransmitter dopamine. Inomngcipheko omncinci weempembelelo zesondo. Enyanisweni, abanye oogqirha bamisela u-Wellbutrin kunye nomnye u-SSRI ukukunceda ukukhawuleza ukuhlawula i-libido.
> Imithombo:
> Iinqununu zezeMpilo zabaThengi. "Ukusebenzisa i-Antidepressants yokuphatha uxinzelelo: Ukuthelekisa ukusebenza, ukhuseleko kunye nexabiso."
> Clinical Mayo. "Abaxinzelelo: Ukukhetha Lowo Ulungele Wena."
> UMichael Camilleri, MD "uSerotonin kwiTranstiestest Tract." I-Curr Opin Endocrinol I-Diabetes . 2009 Feb; 16 (1): 53-59.
> Thomas J.Moore, AB; UDonald R. Mattison, MD, MS. "Ukusetyenziswa kwabantu abadala ngokusetyenziswa kwezidakamizwa kunye nokuhlukana ngoSondo, ubudala, kunye nobuhlanga." JAMA Intern Med. 2017; 177 (2): 274-275. i-doi: 10.1001 / jamainternmed.2016.7507.