I-Wellbutrin - eyaziwayo ngegama layo eliqhelekileyo, i-bupropion-yi-anti-depressant edlalwa ngamanye amaxesha ukuphatha uxinzelelo kwi-bipolar disorder. Umenzi we-Bupropion uthengisa izidakamizwa phantsi kwegama lesithathu, kunye no-Zyban, isichengiselwano esithengiswa ukubanceda abantu bayeke ukutshaya.
Amachiza afumaneka ngokukhutshwa ngokukhawuleza (iipilisi eziyi-75 kunye ne-100 mg) kunye nokukhululwa okuqhubekayo (100 no-150 mg) amafomula (athengiswa njenge-Wellbutrin SR®).
Akucaci isizathu sokuba u-Wellbutrin asebenze ekunciphiseni iimpawu zokudandatheka . I-Chemically, ayihambelani nanoma yimuphi omunye umxhatshazo ophezulu. Nangona kunjalo, uphando lubonisa ukuba lusebenza, kwaye lunokuba luncedo oluthile ngaphezu kwamanye ama-antidepressants ekuphatheni ukudakumba kubantu abanentsholongwane ye-bipolar.
I-Wellbutrin kwi-Bipolar Disorder
I-Anti-depressants , kuquka i-Wellbutrin, isetyenziswa kakhulu kwi-disorder bipolar, nangona kungekho bungqina obuninzi bokhuseleko lwabo kunye nokunceda. Zizinto ezimbalwa ezenzelwe kakuhle, kwenziwa iiprogram zezokwelapha zangexesha elide, kwaye akucaci kakuhle indlela abaxinzelelekileyo abanokusebenzisana ngayo nezimo ezizinzileyo eziqhelekileyo kubantu abanesifo sengqondo sokukhubazeka kwengqondo.
Olunye uphando lweeveki ezili-10 lubonise ukuba u-Wellbutrin wanceda malunga nesiqingatha sabantu abaneengxaki zokugula ngengqondo eyayiphathwa ngeso sigqirha ngelixa ikwaba ne-stabilizers.
Xa echaza izigulane zokulwa neengxaki zentsholongwane zabo, izifo zengqondo zixhalabele "ngokuguquguquka kwemizwelo," apho ixinzelelo lomsindo ngokukhawuleza litshintsha ku-mania, i- hypomania okanye i-mix mix.
Kukho ubungqina bokuthi i-Wellbutrin inokuba nexabiso elincinci "lokutshintshwa komntu" xa kuthelekiswa nezinye iindidi zokuxhatshazwa, ezifana ne-tricyclic antidepressants kunye ne-norepinephrine-serotonin reuptake inhibitors (SNRIs). Phantse i-10% yezigulane kwisifundo seveki-10 sabona ukwanda okukhulu kwiimpawu zabo zomntu, xa kuthelekiswa nama-29% abo bathabatha iSNRI.
Ukutshintsha kwemizimba kubonakala ngathi kuvela rhoqo kubantu abantu abane-bipolar I abaphatha izidandlululo. Ngoko ke, iingcali zincoma ukuba izigulane ze-bipolar I zichazwe kuphela izidandathelwana ngokudibanisa neemvakalelo ezizinzileyo.
Ukuqala i-Wellbutrin: Izikhokelo eziqhelekileyo
Ugqirha wakho unokwenzeka ukuba ufuna ukuqala kwiWorbutrin okanye iZyban kwisilinganiso esezantsi uze wandise umlinganiselo wakho, ngenxa yengozi yemiphumo emibi .
Xa uqala ukuthabatha u-Wellbutrin, i-dosage yakho yokuqala ayifanele ibe ngaphezu kwe-150 mg / ngosuku. Oku kunganyuswa kungabi ngaphezu kwama-300 mg / ngosuku ngosuku lwesine xa sisetyenzisiwe njengoncedo lokuyeka ukutshaya, kwaye ekugqibeleni kube ngu-400 mg (ukukhululwa ngokukhawuleza) okanye 450 mg (ukukhululwa ngokukhawuleza) xa kusetyenziswa ukuphatha uxinzelelo.
Kwimitha ye-400-450 mg / usuku lwakho umngcipheko wokubamba i-triples, nangona kusekho kakhulu, kuncinci kakhulu: ezine kuzo zonke i-1,000 abantu bafumana ukuxhamla kwi-Wellbutrin kwiqondo eliphezulu. Izigulane ezinokubandezeleka, ukungazinzi okanye ukulala usweleko kufuneka zihlale kwidaysi ephantsi kwaye / okanye ukwandisa umyinge ngokuthe ngcembe. Kungathabatha enye kwiiveki ezine ukuya kwizigulane ezithatha u-bupropion ukuziva uncedo olupheleleyo.
Imiphumo echaphazelekayo yezona zinto ziqhelekileyo zibandakanya intloko, umlomo owomileyo, isicathulo, kunye nokulala.
Nangona ezininzi izidandlululo zibonakala zibangelwa okanye zigalelo ekuzuzeni ubunzima, i-Wellbutrin / iZyban ithathwa ngokuba "isisindo sokungathathi hlangothi," kwaye abantu abaninzi baxela ukulahlekelwa ubunzima kunokuba bafumane ubunzima ngelixa bethatha amayeza.
Izilumkiso kwi-Wellbutrin / iZyban
Nazi ezinye izinto omele ulinde xa uthatha le nyilisi:
- Ipesenti encinci yabantu bafumana i- anorexia ngelixa bethatha i-bupropion, ngoko-ke izigulane ezineembali ze-anorexia nervosa okanye i- bulimia , okanye kunye nembali yokubanjwa, akufanele zithathe eli gciwane. Enyanisweni, ezinye iimithombo zincoma ukuba iBupropion ingathathwa nantoni na ongenakukwazi ukulahlekelwa ngaphezu kwama-5% okwangoku umzimba.
- Ukuba uthabatha u-MAOI onxinzezelekileyo, kufuneka ulinde ubuncinane iiveki ezimbini emva kweqondo lakho lokugqibela lalo mayeza ukuba uqale u-Wellbutrin / iZyban.
- I-Bupropion ayiyazi ukuba iyingozi ngexesha lokukhulelwa okanye unesi, kodwa ke, umgqirha wakho kunye nodokotela wezilwanyana kufuneka awazi onke amayeza owenzayo ngamaxesha onke.
- Ukuba uphoswa i dose, SKIP IT. Umngcipheko wokubamba i-dose ixhomekeke, kwaye ukuphindaphinda kabini kunokubangela ukuba uthathwe.
- Ungalokothi uthathe zombini u-Wellbutrin no-Zyban. Konke oya kwenzayo ukwandisa umlinganiselo kwinqanaba eliyingozi.
- Ukusetyenziswa - ngokugqithiseleyo ukusetyenziswa - utswala kotywala kwandisa umngcipheko wokubamba ngexesha lokuthatha ubuqili.
- Ukunyamekela kufuneka kuthatyathwe xa kudibanisa i-Wellbutrin okanye i-Zyban kunye ne-anticonvulsant imithi ye-phenytoin (igama elithi brandant Dilantin), i-carbamazepine (igama lomthi weTegretol) (eliqhelekileyo lisetyenziselwa ukhathaza i-bipolar disorder), okanye i-phenobarbital, okanye kunye neyeza lezilonda cimetidine (igama lomthi iTagamet ).
Imithombo:
Ukusebenzisana kaZwelonke kwiMpilo yengqondo. Inkcazelo yeBupropion (Wellbutrin).
Pacchiarotti I et al. I-International Society ye-Bipolar Disorders (ISBD) ingxelo yeqela lokusebenza ngokuxhatshazwayo kwiingxaki ze-bipolar. I-American Journal ye-Psychiatry. 2013 Nov; 170 (11): 1249-62.
Post RM et al. Ukutshintsha kwemiModi kwixinzelelo ye-bipolar: ukuthelekisa i-venlafaxine, i -propropion, kunye ne-sertraline. IBritish Journal of Psychiatry. NgoJulayi 2006, 189 (2) 124-131.