I-Topiramate iSebenza ngokuPhezulu kwiNkunkuma yokuSebenzisa utywala
I-Topiramate, isicatshulwa sokulwa nesigxina esiqhelekileyo esisetyenziselwa izigulane ezinesiqhwaba, sinempumelelo kakhulu ekuncediseni abantu abanxilisayo ukuba bayeke ukusela. Kuyinto evela kwi-sugar-monosaccharide D-fructose. Izifundo zexesha elide zibonisa iingxaki ezimbalwa ezinxulumene nokuthatha le nkunkuma kubantu abaninzi.
Le yonyango lokuqala eliye labonisa ukuba liyasebenza kubaxhaphali bezobisi ababeselayo.
Ezinye iziyobisi "ukuyeka ukusela" kuphela kulabo abasele bayeke ukusela.
Abanxila bafumana utywala xa bekhupha i-dopamine yeekhemikhali kwingqondo. I-Topiramate isebenza "ngokuhlamba" i-dopamine engaphezulu. Ngamanye amazwi, izidakwa azifumaneki nokuzonwabisa.
Ubungqina bezonyango kwiPilisi yoTywala
Ekubeni i-Topiramate iboniswe kuqala njengonyango lokusetyenziswa kakubi kotywala, kukho uphando oluninzi olwenziweyo ukuvavanya ukusebenza kwalo. Phantse zonke zezi zibonise ukuba iziyobisi ziphumelele okanye zithembise. Nangona kunjalo, akuvunywanga ngokukodwa yi-FDA yokuphatha ukusetyenziswa kwezidakamizwa zokusetyenziswa kotywala.
Ngokomzekelo, uphando oluthile lufumanise ukuba abaphuza kakhulu abanamathuba ayisithandathu okuba bahlale bengenayo inyanga ukuba bawathabatha amayeza, nangona amanani amancinci. Abathathi-nxaxheba abathatha indawo ye-placebo babenokuba ngamathuba amane okusela kakhulu ngexesha lovavanyo lweklinikhi.
Bonke abathathi-nxaxheba abangama-150 basebesela kakhulu ngaphambi kokuba bathathe i-Topiramate kodwa baceba ukuyeka.
Iziphumo ezongezelelweyo ezikufundwa kolu kliniki ziquka:
- Emva kweenyanga ezi-3, iipesenti ezingama-24 zeqela le-Topiramate liye layeka ukuqhubeka ngenyanga. Iipesenti ezi-4 kuphela kwiqela le-placebo zineenyanga enye zinyusa.
- Kwiqela le-Topiramate, iipesenti ezingama-50 azizange zinyanzele ngenyanga yokugqibela, xa kuthelekiswa nama-16 ekhulwini abo bathatha indawo ye-placebo.
- Iipesenti ezingama-50 zeqela le-Topiramate lichaze amancinci okusela utywala, xa kuthelekiswa nama-15 ekhulwini kwiqela le-placebo.
Uphononongo olutshanje lubonakala lukhusekisa la ma-akhawunti, nangona kungenjalo kubangelwa manani afanayo. Olu vavanyo olulawulwa lubandakanya abathathi-nxaxheba abangama-371, isiqingatha sawo sathola i-topiramate kunye nesiqingatha se-placebo. Kwakhona, i-topiramate iboniswe ukuba isebenze ngakumbi ngeveki ezine yesifundo kunye neentsuku ezininzi zokusela ezichazwe phakathi kwabo babethathe.
Iinzuzo zePilisi yoTywala
I-Topiramate iyinto entsha ngoba inika uncedo ngokukhawuleza kotywala. Kwakhona ivula iindlela ezintsha zokunyangwa kwemithi yokusetyenziswa kotywala kotywala.
Iziphumo zezifundo eziye zenziwa ngoku zibonisa ukuba kwanamaqondo aphantsi aphezulu ayenamandla okuphucula ukuxhalaba kunye nokungazinzi kwemiqathango yokuyeka ukusela. Kwakhona kwavelisa umphumo omkhulu ekuphuculeni ukugcinwa kwesondlo nokunciphisa ukusetyenziswa kotywala .
Iimpembelelo eziPhambili ze-Topiramate
Nangona i-Topiramate inokukunceda ngxaki yokusela, unokufumana imiphumo emibi. Kuhlala kubalulekile ukukhumbula ukuba wonke umntu uhlukile kwaye oku akuyiyo yonyango-yonke into yonxila.
Phakathi kwezona zinto zibaluleke kakhulu kwiinkxwaleko zokubheka izizathu zokuzibulala, ukuxhalabisa okanye ukrakra, okanye enye inguqu engaqhelekanga.
Kuyafana nemiphumo emibi abanye abantu abajamelana nayo kwiyeza lokuyeka ukutshaya, i-Chantix . Oku kuyinyani ngokunyanisekileyo nakubani na onomlando wokudakumba okanye ezinye iinkxalabo zempilo yengqondo. Esi silumkiso simele sithathwe ngokungathí sina kwaye into enyanzelekile ukuxoxa ngayo nodokotela wakho.
Ezinye iziphumo eziphambili ze-topiramate ziphambili ngokomzimba:
- intloko
- ukufuduka kwamehlo okungalawulwayo kunye nokuthungatha inxalenye yomzimba wakho
- utshintshe ukukwazi ukunambitha ukutya
- ixesha lokuya esikhathini elingekho kunye nokuphuma kwexesha lokugqithisa
- kuzela nobuthathaka
Kucetyiswa kwakhona ukuba amayeza ayenyuka ngokuthe ngcembe ekuqaleni, kwaye wehla kancane kancane ngaphambi kokuba uyeke ukuyithatha.
Kubalulekile ukunqanda ngokukhawuleza le meyile ngaphandle kwemvume yakho.
Olunye utywala
Abaphandi baye bafuna ixesha elide ukunyanga utywala. Kukho imithi emithathu kuphela evunyiweyo yi-FDA ekuphatheni izidakwa zase-US Ezi zi-Antabuse (disulfiram), naltrexone, kunye neCampral (acamprosate).
I-Antabuse ayinciphisi iminqweno, yenza nje umntu oselayo agule xa edla utywala. I-Naltrexone kunye neCampral ziye zaboniswa ukunciphisa izifiso ezidakwa ziye zayeka ukusela.
Imithombo
- > Johnson BA, et al. I-Topiramate yokuPhatha ukuThengiswa koTywala: I-Trial Control Control. JAMA. 2007; 298 (14): 1641-51.
- > Johnson BA. I-Pharmacotherapy yoLimo lweNkunkuma yoTywala. Isemgangathweno. 2017.
- > Swift RM, i-Aston ER. I-Pharmacotherapy yoTywala lokuSetyenziswa kweTywala: IiNtsholongwane zamanje kunye neeNtsholongwane. I-Harvard Review of Psychiatry. 2015; 23 (2): 122-133.
- > Ilayibrari yeSizwe ka-US yamayeza. Topiramate. Medline Plus. 2015.