Ngokutsho kwe-US Food and Drug Administration, kukho ingozi eyongezelelekileyo ye- serotonin syndrome ngenxa yokudibanisa i-serotonin reuptake inhibitors (i-SSRIs) kunye ne-serotonin ekhethekileyo i-norepinephrine reuptake inhibitors i- SSNRIs ne-migraine ye-headache imithi ebizwa ngokuthi i-triptans.
I-Serotonin Reuptake Inhibitors (i-SSRIs)
Kukholelwa ukuba ingqondo iqulethe iindidi eziliqela ezihlukeneyo zezithunywa zamakhemikhali (i-neurotransmitters) ezisebenza njengama-intsebenziswano oonxibelelwano phakathi kweeseli ezahlukeneyo zobuchopho .
I-Serotonin yintsholongwane ebalulekileyo ekulawuleni imisebenzi eyahlukeneyo yomzimba kunye neemvakalelo. Amanqanaba e- serotonin aphantsi adibene nexinzelelo kunye nokuxhalabisa.
I-SSRI inqanda ukubuyiswa kwakhona kwe-serotonin kwingqondo. I-Reuptake yinkqubo apho i-neurotransmitters engqondweni ibuyiselwa kwakhona kwaye ikhutshwe okanye iphinde isetyenziswe ukusetyenziswa kwangaphambili. Oku kubangela ukwanda kwamanqanaba e-serotonin, okubangele ukuhlaziywa kwemizwa, ukunciphisa uxhalaba kunye nokuvinjelwa kwexhala . I-SSRI ithathwa njengonyango wokuqala kumnxeba wokuphazamiseka kwesifo kwaye iquka:
- Celexa (citalopram)
- Luvox (i-fluvoxamine)
- Prozac (i-fluoxetine)
- Paxil (paroxetine)
- Zoloft (sertraline)
I-Serotonin-Norepinephrine Reuptake Inhibitors (SSNRIs)
I-SSNRI inqanda ukubuyiswa kwakhona kwe-serotonin kunye ne- norepinephrin ebuchosheni. I-Norepinephrine ngumthunywa weekhemikhali kwingqondo echaphazela ukulala nokuqapha. Kukholelwa ukuba iyahambelana nokuphendula uxinzelelo lokulwa-okanye-ukundiza .
SSNRI ziquka:
- I-Cymbalta (duloxetine)
- I-Exexor, i-Effexor XR (venlafaxine)
Triptans
I-Triptans yinkalo yeziyobisi ezisetyenziswa ngokuqhelekileyo ukuphatha unyango lwe-migraine okanye i-cluster headaches. Benza kwi-serotonin receptors kwingqondo, oko kuyachaphazela ama-serotonin.
Imizekelo yama-triptans iquka:
- Amerge (naratriptan)
- Axert (almotriptan)
- Frova (frovatriptan)
- Imitrex (sumatriptan)
- U-Maxalt no-Maxalt-MLT (rizatriptan)
- Relpax (eletriptan)
- Zomig kunye neZomig ZMT (zolmitriptan)
Ukongeza kwimiba echazwe kwi-advisory FDA, ezinye iziyobisi zihambelana nokuguqulwa kwamanqanaba e-serotonin ebuchosheni, okwandisa umngcipheko we-serotonin syndrome.
I-Tricyclic Antidepressants
I-Tricyclic antidepressants (TCAs) zithiwa ngamachiza '"amathathu atyhilo" isakhiwo seemodeli. Ngaphambi kokungeniswa kwe-SSRIs ekupheleni kweminyaka yama-1980, ii-TCA zazingumntu okhethekileyo kunyango lwengxaki enkulu yokuphazamiseka , ukuphazamiseka kwesifo kunye nezinye iingxaki zokuxhalabisa. Ii-TCAs zisetyenziselwa ukunyanga iintlungu ezithile zesifo kunye ne-enureis yasebusuku (i-bedwetting). Kukholelwa ukuba i-TCAs isebenze ukwandisa amanqanaba e-norepinephrin kunye ne-serotonin ebuchosheni.
Imizekelo yeTCA iquka:
- Elavil (amitriptyline)
- ETofranil (imipramine)
- Sinequan (doxepin)
- I-Anafranil (i-clomipramine)
I-Monoamine Oxidase Inhibitors (MAOIs)
I-MAOIs yiklasi le- anti-depressants believed to increase levels of norepinephrin, serotonin kunye ne-dopamine kwingqondo. Ziyasebenza ekwenzeni unyango olukhulu lwentlungu, ukuphazamiseka kwesifo kunye nezinye iingxaki zokuxhalabisa. Ngenxa yokubambisana okunobungozi kunye nokutya okuthile, iziyobisi kunye nezinye iziyobisi, ii-MAOI zidlalwa njengonyango lokugqibela lokunyanga.
Imizekelo ye-MAOI iquka:
- Nardil (phenelzine)
- Parnate (tranylcypromine)
- Marplan (isocarboxazid)
- Emsam (selegiline)
Ezinye izixinzelelo
Imizekelo yezinye izidakamizwa ziquka:
- Wellbutrin (bupropion)
- Desyrel (i-trazadone)
Ezinye iiMicrocyatric Medication
- BuSpar (buspirone)
- Eskalith (lithium)
Ii-Analgesics (Ubuhlungu Bokubulala)
- ICodeine
- Fentanyl
- Tramadol
I-Antibiotic / Antiretroviral Medication
- Zyvox (linezolid)
- Norvir (ritonavir)
Izidakamizwa / iziTyhulo zeDrama
- I-Hypericum Perforatum (iSt. John's Wort)
- Ginseng / Panax
Iidrama
- Amphetamines
- ICocaine
- I-LSD (i-lysergic acid diethylamide)
Olu luhlu aluthethiwanga ukuba luhlanganiswe konke. Ukuze ugweme ukwandisa umngcipheko wokuphucula i-serotonin syndrome, xelela ugqirha wakho malunga nawo onke amayeza kunye nezondlo zokutya ozithathayo.
Ukuba uhlakulela iimpawu ze-serotonin syndrome, khangela uncedo lwezonyango.
Imithombo:
> Umtshini, uBetina C. "uSerotonin Syndrome." I-Journal ye-Neuroscience Nursing . Epreli 2006. 38 (2): 102-105.
> Ulawulo lweZiko lokuTya kunye neDrug. Ubomi-obunobungozi beSerotonin Syndrome kunye nokusetyenziswa okuhlanganisiweyo kwama-SSRIs okanye ama-SNRIs kunye neMilptan Medication. Julayi 19, 2006.