I-retina inokusebenza njengefestile kwingqondo kunye nomsebenzi wayo
Ngokutsho kwiphononongo kwi- Biological Psychiatry, ukuhlolwa kwamehlo okukhethekileyo kunokunceda ukuba umntwana ungaphezu komngcipheko oqhelekileyo wokuphucula izifo zengqondo ezifana ne- bipolar disorder okanye i- schizophrenia .
Ukuhlolwa Kwamehlo Njenge-Predictor of Risk for Bipolar Disorder
Kule sifundo esincinci, uvavanyo olubizwa ngokuba yi-electroretinography (ERG) lisetyenziselwa ukuhlola i-retina kunye nendlela esebenza ngayo.
I-retina iyinxalenye yesimiso se-nervous central kwaye itholakala ngasemva kweso. Iqulethe ezimbini iintlobo zentlupheko yokukhanya: iintonga kunye neebhondi.
Izindonga zibona abamnyama nabamhlophe kwaye zibalulekile ukuba zibone kwiimeko eziphantsi zokukhanya kunye nombono wendlela. Iikona, ngakolunye uhlangothi, khangela umbala. I-Electroretinography inikeza umlinganiselo weentonga kunye neepone kwi-retina.
Nangona abaphandi besazi ukuba ukuhlaziya okungaqhelekanga kwafunyaniswa kubantu abafumene ingxaki ye-bipolar kunye ne-schizophrenia, iziphumo zesifo kunye namayeza asetyenziswa ukunyanga zenza ukuba iziphumo zingasetyenziselwa iinjongo zophando.
Yingakho, kulolu cwaningo, abaphandi bavavanya i-retinas yabantu abadala abasemgangathweni (abaneminyaka yobudala abaneminyaka engama-20) ababengumngcipheko ophezulu wokuvelisa ingxaki ye-bipolar okanye i-schizophrenia, ngenxa yokuba nomzali omnye one-bipolar disorder okanye i-schizophrenia. Iimvavanyo ze-retina zale nzala enempilo zaye zafaniswa neqela lokulawula iintsapho zabo ezingenayo imbali yezo zifo.
Iziphumo zityhila ukuba kwiqela eliphezulu lomngcipheko wezofuzo, ukukwazi ukukhanya ukuvula izibonda kuye kwacutha kakhulu, xa kuthelekiswa neqela lolawulo. Esi siphumo sahlala siphumelele nangona abaphandi beesifundo belawulwa iminyaka, ubulili kunye nexesha lokuvavanya. Kwakungekho umahluko kwiimpendulo zeeconsi phakathi kwamaqela amabini.
Zithini Ezi Ziphumo?
Iphakamisa ukuba impendulo yeentonga ze-retina zingasebenza njenge-biomarker yokuqala yengozi yokuphucula i- bipolar disorder okanye i-schizophrenia. Olu lwazi lungaba luncedo kwiimvavanyo zofuzo ezizayo kunye nophando lokuthintela.
Oko kuthethwa, ababhali besicatshulwa sokuthi ukuza ngeenkcukacha ezichanekileyo zokuthi kutheni kukho ukunciphisa umsebenzi wokunciphisa intonga kwi-high bloodtic seed inzalo kunzima. Ngokusekelwe kwizifundo zesilwanyana zangaphambili, ziphakamisa ukuba kunokungaqhelekanga kwimveliso okanye ukuvalelwa kweentlobo zeekhemikhali zobuchopho (ezibizwa ngokuba yi- neurotransmitters ) njenge-dopamine okanye i-serotonin.
Enye ingcamango engachaza oku kufunyaniswa kukuba kukho inkqubo yokuphuhliswa engavumelekanga kwintliziyo yabantwana abazalwa kwintsapho eneenkcukacha ezinzulu zengxaki yokuguquguquka kwe-bipolar okanye i-schizophrenia. Khumbula, i-retina yincinci yengqondo, ixhunywe kuyo nge-nertic optic, ngoko isebenza njengefestile kwingqondo.
Ekugqibeleni, unokuba uzibuze ukuba impendulo encinci yeentonga zikhokelela kwiingxaki zangempela kwiingxaki ze-bipolar kunye ne-schizophrenia? Kunokwenzeka, njengoko abantu abanezifo zengqondo banokuba neengxaki ezincinane kodwa ezibalulekileyo ngendlela abazibona ngayo ihlabathi.
Oku kunokuba negalelo ekusebenziseni kwabo ukukhubazeka.
ILizwi
Kubalulekile ukuba uqaphele ukuba ezinye iziphumo ziye zafumanisa izikhalazo ze-ERG kubantu abaneengxaki zengqondo ezifana neengxaki zonyaka, i-autism, umlutha weziyobisi, kunye nengxaki yokudakumba okukhulu. Oku kuphela kusekela umfanekiso omkhulu-ukuba utshintsho kwindlela i-retina esebenzayo (njengoko ilinganiswe ngu-ERG) lunokunceda ngelinye ilanga ekuxilweni kwesifo sengqondo.
> Imithombo:
> Hébert M. Impendulo yokuphendulela ekukhanyeni kwintsana encinane engabonakaliyo kwiingozi eziphezulu zobomi beengxaki zeengqondo ze-neuropsychiatric. Biol Psychiatry . 2010 Feb1; 67 (3): 270-4.
> Lavoie J, Maziade M, Hébert M. Ingqondo ngokusebenzisa i-retina: i-flash electroretinogram njengesixhobo sokuphanda izifo zengqondo. Prog Neuropsychopharmacol Biol Psychiatry. 2014 Jan 3; 48: 129-34.
> Schwitzer T, Lavoie J, Giersch A, Schwan R, Laprevote V. Intsimi ekhulayo ye-retinal electrophysiological inzululwazi kwiphando lwengqondo: Ukuphononongwa kweziphumo kunye neembono kwiingxaki ezinkulu zokudandatheka. J Psychiatr Res . 2015 Ngo-Nov: 70: 113-20.