Ukulawula Utywala-Ukufuna Ukuziphatha nokuvakalelwa
Abaphandi baye badibanisa iproteni efunyenwe kwingqondo ekuziphatheni kokuphuza utywala kunye nobubele kwimiphumo yokuxiliswa kotywala .
Abaphandi kwiYunivesithi yaseWashington babika ubungqina bokuqala obucacileyo kwiimiceba zokuba uphawu lweprotein kinase A (PKA) lulawula indlela yokuziphatha ephuza utywala kunye nobutyebi kwezinye iimiphumo zokuxiliswa kotywala, ngokutsho kweNational Institute of Alcohol Abuse and Alcoholism.
I mpendulo
Ukunikezelwa phakathi kwamanzi alula kunye nezisombululo eziqukethe utshwala, iigundane ezilahlekileyo i-RIIB yamagumbi e-PKA bakhetha isisombululo sotywala ephezulu. Ukongezelela, iiglofu zokungqongqoza izityalo zazingenabuthathaka kunezona eziqhelekileyo ze-PKA kwimiphumo yokudakwa kotywala.
Iprotheni ebandakanyekayo kwi-intracellular communication, i-PKA ikhona kuyo yonke ingqondo. I-PKA phosphorylates ezininzi zeeprotheni zeprotheni kwaye zilawula i-expression geni, ngaloo ndlela ziguqula izakhiwo zombane zeseli kwaye, mhlawumbi, isebenzi yeseli kunye noqhagamshelwano phakathi kwe-neurons.
Amagundane alahlekileyo I-RIIB, enye yeeselwane ezi-6 ezifakela i-PKA, ukuguqulwa kwamathuba kwintsebenzo ye-PKA, imeko abaphandi bayakholelwa ekutshintsheni impendulo yabo kwiipropmacologic zotywala.
UkuLawula Utywala
Uphando lwangaphambili kwiinkcubeko zombini kunye nezilwanyana kubonisa ukuba ukusetyenziswa kotywala kunokuchaphazela umsebenzi we-PKA, "watsho u-Enoch Gordis, MD, uMlawuli we-NIAAA, owanike inkxaso ngenkxaso-siseko.
"Yintoni entsha malunga nalo msebenzi yinto echaseneyo - ukuba, ubuncinane kwimodeli yezilwanyana, i-PKA inokulawula ukusetyenziswa kotywala kunye neminye imiba yempendulo yotywala."
Todd Thiele, Ph.D., iSebe lezengqondo kunye ne-Alcohol and Drug Abuse Institute, iYunivesithi yaseWashington, kunye noogxa bakhe bahlola ukuziphatha kokusela ku-12 iigundane eziqhelekileyo kunye neigundane ezili-12 zokukhwaza ngokuguqulwa kwinqununu ye-RIIb ye-PKA.
Nangona akukho nantlukwano efunyenwe phakathi kwamaqela amabini ekukhethweni kwintlobo yesisombululo esiphumileyo okanye esichukumisayo, amagundane kunye nokuguquguquka kwe-PKA ukusela ngokuphindaphindiweyo kabini kwisisombululo sesiphuzo se-20 sepesenti njengegundana eliqhelekileyo.
Imiphumo yokuThatha
Abaphandi baphinde baqikelele ixesha elifunekayo kwiigundlo ezixutywayo ukuze baphinde bafumane i-reflex efanele. Bawafaka amaqela amabini eentlanzi kunye notywala baze bawabeka emqolo wabo kwimigodi ye-plastiki. Iigundlo ze-Knockout zifumene ngokukhawuleza kwiimpembelelo zokusela, ukubuyela kwakhona emva kwemizuzu engama-65 xa kuthelekiswa nemizuzu engama-90 kwiigundane eziqhelekileyo.
"Kungenzeka ukuba iigundane ezine-RIIB zatshintsha kakhulu i-ethanol ngenxa yokuba umsebenzi we-PKA uphazamiseka kwiziganeko zobuchopho ezibandakanyekayo ekujonganeni nomvuzo we-ethanol," kutsho uDkt. Thiele. "Ngoku kubalulekile ukucacisa ukuba ziphi iingingqi zeengqondo ze-RIIB ziqulunqa le miphumo."
> Imithombo:
> Thiele, TE, et al. Ukusetyenziswa kwe-Ethanol ephakamileyo kunye nokuqonda okufutshane kwi-Ethanol-Indeded Sedation in Protein Kinase A-Mutant Iiice. " I-Journal ye-Neuroscience ngoMeyi 2000