Nali iindaba ezilungileyo ukuba unomdla ngemiphumo yeLamictal (lamotrigine): Esi sichaphazelekayo asiyi kuthintela ubunzima bakho. Ukuba nantoni na, unako ukulahlekelwa isisindo ngenxa yeLamictal kunokuba ufumane ubunzima, kodwa mhlawumbi indlela, utshintsho luya kuba luncinane kakhulu.
Isiphumo seLamictal kwisisindo sele sifundeke kakhulu kwaye izilingo ezahlukeneyo zekliniki zifumene umphumo omncinci kwisisindo.
Enyanisweni, abanye abaphandi baye bajonga le nkunkuma njengonyango olunokwenzeka lokunyanyisa kwaye njengonyango lweengxaki zokutya . Olu lwazi lufanele luqinisekise abantu abaneengxaki zokugula ngengqondo ngenxa yokuba amayeza amaninzi asetyenziswa ukunyanga imeko angenza ukuba uzuze umzimba.
I-Lamictal no-Weight Gain or Loss
I-Lamictal yipilisi ye-anticonbulsant engasetyenziswa ekuphatheni iziphazamiso zokungena, ezifana nokuhluthwa. Isetyenziswe kwakhona njengesimo sokuzinza kwimeko yokukhubazeka kwe-bipolar.
Kwiimvavanyo zonyango zokuqala ezibandakanya izidakamizwa, ama-5 ekhulwini labantu abanesifo sokuhluthwa balahlekelwa isisindo ngelixa besethatha i-Lamictal, ngelixa phakathi kwe-1 ne-5 ekhulwini yezigulane ezineengxaki zokugula kwengqondo zizuze isisindo ngelixa esichengeni. Abaphandi abazange bachaze ukuba bunzima kangakanani izigulane ezifumanekayo okanye ezilahlekileyo.
Okwangoku, uvavanyo luka-2006 oluqhathaniswa nemiphumo yeLamictal, i-lithium, kunye ne- placebo yafumanisa ukuba ezinye izigulana ezithola uLamictal zanomzimba, ezinye zalahleka, kwaye zininzi zahlala malunga nobukhulu obufanayo.
Ukuguquka kwesisindo ngokuqhelekileyo akuzange kube yimiba emibini. Izigulane ezigqithisileyo ezithatha uLamictal zalahlekelwa ngumyinge weepounds ezine, ngoxa izigulane ezingapheliyo zihlala zifana.
Ubunzima bokufumana iMithiyo ye-Bipolar
Ukunyusa inzuzo kwiziyobisi ezisetyenziselwa ukunyangwa kwengxaki ye-bipolar ngelishwa ngelanga eliqhelekileyo.
Iimpawu ezinjengezinto eziqhelekileyo eziqhelekileyo ezisetyenziswa kwi-bipolar disorder-ngokukodwa, i-lithium ne-Depakote (valproate) -bafumana umngcipheko omkhulu wokufumana ubunzima.
Ukongezelela, imithi ye-antipsychotic medication Clozaril (clozapine) kunye neZyprexa (i-olanzapine) ithambekele ekuzuzeni inzuzo ebalulekileyo kubantu abayithathayo. Ekugqibeleni, ezinye izidalwa zokudandathelana-ngokukodwa, i-Paxil (i-paroxetine) ne-Remeron (i-mirtazapine) -xhamene nokufumana ubunzima.
Ngoko ke, ukuba sele usukhulu kakhulu, wena kunye nesifo sakho sengqondo singathanda ukucinga ukuba unokufumana ubuninzi obuninzi bokufumana ubunzima ekuqaliseni imithi yakho yeyeza kwi-bipolar disorder. Ngaloo ndlela kuphela, uLamictal unokukhetha okulungileyo.
I-Lamictal njengeNyango eNgenako yokunyusa
I-Lamictal iphinde ifundwe njengendlela yokunyanga ukunyamezela kubantu abangenasifo sokuhlutha okanye ukuphazamiseka kwengqondo.
Kwimvavanyo encinci yeklinikhi ebandakanya abantu abangama-40 abaqhutywe ngo-2006, abaphandi banomdla abaye bathabatha iLamictal okanye i-placebo ukuya kwiiveki ezingama-26. Wonke umntu uthatha inxaxheba kwiphononongo wayenomxholo wesikhokelo somzimba (BMI) ophakathi kwe-30 no-40, owambeka ngokugqithiseleyo kwibala eligqithiseleyo. Abo bathatha uLamictal balahlekile, ngokuqhelekileyo, bangaphantsi kweepounds ezili-10.
Abo babamba i-placebo, okwangoku, balahlekelwa malunga neekhilo ezili-7, ngoko ngoxa abo bathatha uLamictal balahlekelwa bunzima, abazange baphulukane nakho konke okuninzi.
Olunye uhlolisiso, lo ngo-2009, lucinga ukuba uLamictal uyonyango lokugula okuxilisayo. Okokufunda kwakuquka abantu abangama-51 abanemeko-26 kubo bafumana uLamictal, ngelixa i-25 ithola indawo ye-placebo.
Abo bathatha uLamictal balahlekelwa ubunzima kunabo abahlala kwindawo ye-placebo (malunga nama-2.5 iipounds ngokumalunga ne-third-thirds of a pound), kwaye babe neempembelelo eziphambili kwiishukela zegazi kunye nemiphumo yokuhlolwa kwebhuleterol yebhanki. Nangona kunjalo, uLamictal akazange abonakale echaphazela ezinye iinkalo zeengxaki zabo zokutya ngokubhekiselele kwi-placebo.
Imithombo:
Bowden C et al. Impembelelo yeLamotrigine kunye neLithium kwi-Weight kwi-Pure and Nonobese Patients With Bipolar I Disorder. I-American Journal ye-Psychiatry . 163.7 (2006): 1199-1201.
Guerdijikova AI et al. I-Lamotrigine ekhatyweni kweengxaki zokutya ezidliwayo kunye nokunyanya kuninzi: ityala le-monotherapy elilawulwe ngokungaqhelekanga, elilawulwa yi-placebo. I-Clinic Psychopharmacology. 2009 ngoMeyi; 24 (3): 150-8.
Hasnain M et al. Ukunyamekela ingqalelo kwisicatshulwa se-psychotropic esichaza kunye nokutshintsha. I-Postgraduate Medicine. 2013 Sep; 125 (5): 117-29.
Meredith, CH. I-single-center, i-blind-blind, i-placebo elawulwa ukuhlolwa kwe-lamotrigine kwonyango lokunyanyisa kubantu abadala. Umbhalo we-Clinical Psychiatry (nge-PubMed) 67.2 (2006): 258-62.
Pickrell WO et al. Ukuguqulwa kwesisindo ehambelana nezidakamizwa zokulwa ne-antiepileptic. I-Journal ye-Neurology, i-Neurosurgery kunye ne-Psychiatry. 2013 Jul; 84 (7): 796-9.