Ukuthelekisa phakathi kweentlobo ezimbini ze-Antidepressants
I-Monoamine oxidase inhibitors (i-MAOIs) ithathwa njengelona lisebenza ngokugqithiseleyo kwi-arsenal yezokwelapha. Basebenza ngokuvimbela i-enzyme monoamine oxidase kwingqondo.
Ngakolunye uhlangothi, zisetyenziselwa ukuphatha ukudakumba ngaphezu kwezifo ezininzi ezinxulumene nexhala, kuquka ukuphazamiseka kwesifo (PD).
Basebenza ngokuvimbela ukubuyiswa kwakhona kwe-serotonin kwingqondo, okwenza ukwanda kwe- serotonin .
I-MAOIs isebenza njani?
Kukholelwa ukuba ingqondo iqulethe iindidi eziliqela ezihlukeneyo zezithunywa zamakhemikhali (i-neurotransmitters) ezisebenza njengama-intsebenziswano oonxibelelwano phakathi kweeseli ezahlukeneyo zobuchopho. Ezi zithunywa zeekhemikhali zizinto ezinomzimba ezinokuchaphazela ukukhathazeka, ukutya, ukuxhalaba, ukulala, intliziyo, izinga lokushisa, ukugonywa, ukwesaba, kunye nezinye izinto ezenzeka kwingqondo nangokwenyama.
I-Monoamine oxidase (MAO) yi-enzyme eyenza ihlaziye okanye idibanise ama-neurotransmitter amathathu anxulumene nengqondo kunye nexhala: i-serotonin, i- norepinephrin , ne- dopamine . I-MAOI inciphisa umsebenzi we-enzyme i-MAO, ekhokelela kumanqanaba aphezulu e-norepinephrine, i-serotonin, kunye ne-dopamine kwingqondo. Oku, kukhokelela ekuphuculeni imizwa kunye neempembelelo zokulwa.
Iintlobo zale nyuksi ziphucula umgangatho kunye nefuthe elichasayo.
I-SSRIs isebenza njani?
I-Serotonin yintsholongwane ebalulekileyo ekunyukeleni imisebenzi eyahlukeneyo yomzimba neemvakalelo, kubandakanywa nemizwa yethu. Amanqanaba e-serotonin aphantsi adibene nexinzelelo kunye nokuxhalabisa . Njengoko igama lithetha, i-SSRI inqanda ukubuyiswa kwakhona kwe-serotonin kwingqondo. Oku kubangela ukwanda kwe-serotonin kwingingqi yengqondo ebizwa ngokuba yi-synaptic cleft, eyindawo encinane phakathi kweeseli zengqondo.
Ukuba i-MAOI iSebenze ngakumbi, Kutheni ii-SSRI ezininzi zibhalwa ngokuthe rhoqo?
I-SSRI ngokuqhelekileyo iyona khetho lokuqala kunyango lokudandatheka ngenxa yokuba, ngaphaya kokusebenza ngokufanelekileyo, baneengxaki ezimbalwa neziphumo ezibi. Ngenxa yezithintelo zokutya kunye neengxakini malunga nokuphendula komfutho ophezulu, ii-MAOIs zisetyenziswa kuphela emva kokuba ezinye i-ejenti ziphumelele.
Ezinye iziphumo ezichaphazelekayo ze-MAOI ziquka:
- Ukulala okulala / ukulala
- I sizathu
- Uhudo
- Umlomo omile
- Uxinzelelo oluphezulu (uxinzelelo lwegazi oluphezulu)
- I-Hypotension (uxinzelelo lwegazi oluphantsi)
- Utywala
- Ukutyeba kwakho
- I-Edema (ukugcinwa kwamanzi)
- Ukungasebenzi kwezesondo
- Iimfucu zamathambo
- Ubuthathaka
- Ukudideka
Enye yezinto ezikhangayo ze-SSRIs kukuba zikholelwa ukuba zikhuselekileyo kwaye zivelise iziphumo ezingaphantsi ezingathandekiyo kunezinye iindidi zezidandlululo. Kodwa nawaphi na amayeza angenza iziphumo zecala, ingakumbi ngexesha lokuqala kwonyango. Ezinye iziphumo eziqhelekileyo ezichaphazelekayo ze-SSRI ziquka:
- I sizathu
- Ukungasebenzi kwezesondo, kuquka ukunciphisa umnqweno okanye ubunzima be-orgasm
- Intloko
- Isisu sithukuthele
- Ukhathazeka
- Ukutyeba kwakho
- Ukulala
- Ukungabikho
Ezinye zeziphumo zempembelelo ziya kupheliswa emva kokuba umzimba wakho ulungelelanise amayeza. Ukuba azinako kwaye zixhalabisa, ugqirha wakho unokuzama enye i-SSRI. Nangona i-SSRI isebenza ngeendlela ezifanayo zokuthatha isenzo, ziyahluka.
Imiphumo eminye yempembelelo enye ye-SSRI ayinakuba yingxaki kwenye.
Ngokubanzi, ababoneleli-nkonzo bonyango abayimfuneko ukuba bangawabizi ii-MAOI ngaphandle kokuba babe namava ngala mayeza.
Emininzi Ngeengxaki Zokuxhatshazwa
I-Monoamine Oxidase Inhibitors (MAOIs) . I-MAOIs yinkalo yeengxaki zokuxhatshazwayo eziye zaphuhliswa kuma-1950. Ziyimpumelelo ekuphatheni ukudakumba, ukuphazamiseka kwesifo kunye nezinye iingxaki zokuxhalabisa. Nangona ngokubanzi zisebenza ngokufanelekileyo njenge-SSRIs kunye ne-tricyclic antidepressants (TCAs), zisetyenziswe kangangoko ngenxa yeemfuneko zokulondlo zokutya kunye neengozi zempembelelo ezimbi xa zixutywe kunye neziyobisi ezithile.
I-Monoamine Oxidase Inhibitors (MAOIs) . Ulwazi olungaphezulu malunga nokuthintela ukutya, ukusebenzisana kwezidakamizwa kunye nezinye iziphumo ezibi.
I-Serotonin Reuptake Inhibitors (SSRIs) . Ulwazi olungaphezulu malunga neyeza ezixhatshazelisayo / ezichasayo.