Izithako ezingasebenzi (Abangenayo) kunye Neempembelelo Zabo kwiziyobisi
Xa abavelisi beziyobisi benza iyeza, inezithako ezininzi. Kucacile ukuba, isilwanyana siya kuba nezithako ezisebenzayo-izixhobo zamachiza eziphatha imeko oyenayo ngokwenene ukuba uthathe amayeza. Kodwa kuya kubakho izithako ezingasebenzi. Ezi zithako ezingasebenziyo zibizwa ngokuba yi-excipients.
Ziziphi izinto ezithandekayo?
Abaxhamli baqukwa phantse yonke imirhumo, iyeza-counter-counter-supplements.
Ezi zithako zingenza idayi, i-flavour, izinto ezisebenzayo ukubopha iipilisi ndawonye, izitya kunye nezilondolozo.
Ezinye i-excipients zinceda isilwanyana ukuba sidibanise zibe ngamaqabunga amancinci okwaneleyo ukuba afinyelele kwigazi ngokukhawuleza. Abanye bakhusela ukuzinza komkhiqizo ngoko kuya kuba ngempumelelo ekusebenzeni ngexesha (basebenza njengemilondolozo). Iimvumi nazo zinokuthintela isicatshulwa ekupheliseni kakhulu kusistim kwinkqubo yakho, ukukhusela isisu sokukhupha, okanye ukuphakama kwesantya ngokukhawuleza emva kokuba uthathe izidakamizwa.
Iimfuno okanye izithako ezingasebenziyo kufuneka zifakwe kwi-inert, nto leyo ithetha ukuba ayinayo impembelelo kuwe, kodwa enye inokubangela iimpawu ngokwabo-kwaye mhlawumbi, iimpendulo ezithintekayo-okanye zisebenzisana nezilwanyana ezichaphazelekayo zokudala iziphumo ezingalindelekanga. Izithako ezingasebenziyo kwiyeza elilodwa zingaphinda zisebenzisane nezithako ezisebenzayo kwenye iyeza.
Igama elithi "excipient" livela kwisivakalisi sesiLatini i- excipere , esithetha "ukuphuma."
Ziyintoni Izinto Ezifunyenweyo kwiMil
I-US yokuLawula kunye nokuLawula iDrug idinga ukuvunyelwa kwamagipi asetyenzisiweyo kumachiza amatsha. Phakathi kwezinye izinto, isithako esiluncedo kufuneka:
- Zikhuselekile kwisixa okanye umthamo osetyenziswa kwiziyobisi
- Akunakuchaphazela ukungabi naso (umthamo weziyobisi ezisebenzayo ezikwazi ukusetyenziswa kunye nomzimba) kunye nokusebenza okanye izigqibo zonyango
- Yenziwe ngokuhambelana nemigangatho emihle
I-FDA ivunyile i-excipients ezininzi: Kwakukho izithako ezingapheliyo ezingama-13,000 kwiziko leenkcukacha ze-FDA ekuqaleni kuka-2017. Ziye zavela kwi-acacia (okuyi-thickener based thickener) kwi-zinc sulfate.
Izongezo zeMithi zingathabatha ifom yeflegi. Ngokomzekelo, ioli ye-mandarin, ioli lemon kunye ne-menthol zifakwe kuhlu. Okanye bangaba nemibala enjengama-inks abonakala kwiluhlu lwe-FDA kwiintlobo ezahlukeneyo zeefom.
IziHlomelo zingaba yinto eninzi abantu abayiyiqonda (njengowokukhanya kwe-oyile okanye i-fructose), okanye banokuba yinto enokuthi engaqondakaliyo, njenge-polyvinyl alcohol graft i-polyethylene glycol copolymer (3: 1; 45000 MW) okanye i-linoleoyl macrogolglycerides.
I-excipients eziqhelekileyo ziquka i-cornstarch, i-lactose, i-talc, i-magnesium stearate, i-sucrose, i-gelatin, i-calarum stearate, i-silicon dioxide, i-shellac kunye ne-glaze.
Iingxaki zobunokubakho
Iimfuno zonyango kufuneka zifakwe kwi-inert, oku kuthetha ukuba akufuneki ukuba zisabele ngeentsholongwane ezichaphazela izidakamizwa okanye zibangele iimpendulo kubantu abathatha isibisi.
Nangona kunjalo, ekusebenzeni, abahlali basebenza njengokuba befanele.
Ngokomzekelo, i-calcium salts, esetyenzisiweyo njengezizalisi kwimithi, ingabangela ukuba amathumbu akho angathathi amachiza athile. Kukho iindlela ezininzi apho izitya zingaphazamisa ukutyunjwa kwezinye iziyobisi ukusuka ekubophelelweni ngamachiza kwindlela yokugaya, ukuphazamisa ukuxhamla emathunjini nokunye. Izazinzulu ezenza imishishini kufuneka zithathele ingqalelo ekusebenzisaneni kwazo xa kutyalwa iziyobisi. Enyanisweni, i-excipients kwiyeza elinye liyakwazi ukusebenzisana namanye amachiza kwenye iyeza.
Ukongezelela, ngokuqinisekileyo kunokwenzeka ukuba i-allergic okanye ingavumi ukuba "inert" izithako kumachiza. Ngokomzekelo, abantu abaninzi banomdlavuza we-lactose, kodwa i-lactose isetyenziselwa ukudala iziyobisi. Ukongezelela, abanye abantu bahlaselwa emzimbeni, kodwa iipilisi kunye nezinye iziqulatho zeziyobisi zihlala ziqulethe i-cornstarch njengesiqhekeza okanye ukuzalisa.
Ekugqibeleni, abanye abantu basabela kwiimpawu zemibala ezisetyenziswa kumachiza (kunye nokutya). Umzekelo i-tartrazine okanye i-FD & C yelinen e-yellow # edlalwa ngumdlalo wokutya owenziwe ngokuqhelekileyo.
Umzekelo obonisa ukuba abantu abanokubangela ukunyanga, kunye nendlela yokugwema ukuphendulwa kweempawu ezinokumelana nazo, kunokuthatha umgudu othile, kubandakanya olu luhlu lwezithako ezingasebenziyo kwi-candy candy ezingabangela ukuphendulwa komzimba.
Ukuba unenkxalabo malunga neendwendwe ezisetyenziselwa ukwenza imithi ethile, thetha nekhemistiki malunga nayo. Unako ukufikelela kwisihlomelo sonke sesithako.
Imithombo:
Abrantes, C., Duarte, D., kunye noCreis. Ingqwalaselo yeziMveliso eziMachiza: Ukhuselekile okanye awukhuseli? . Umbhalo weeNzululwazi zeMachiza . 2016. 105 (7): 2019-26.
Perez-Ibarbia, L., Majdanski, T., Schubert, S., Windhab, N., no-U. Schubert. Ukhuseleko kunye nokuHlola okuLawulayo iiDyes eziqhelekileyo zisetyenzisiweyo njengezibonelelo kwiiNkqubo zeMichiza kunye neNutraceutical. I-European Journal yeeMveliso zeMachiza . 2016. 93: 264-73.
US Food and Drug Administration. Idatha yokuSebenza engasebenzi. https://www.fda.gov/Drugs/InformationOnDrugs/ucm113978.htm