Ibhokisi leMnyama eliMcebisi nge-Antipsychotic Clozaril
I-Clozaril (clozapine) yipilisi ye-antipsychotic eye yavunyelwa ukuba isebenziswe kwi- schizophrenia enganyangekiyo kunye nokunciphisa umngcipheko wokuziphatha ngokuzibulala ekuguleni abane-schizophrenia okanye i-schizoaffective disorder abagwetywa ukuba bangasengozini yokuphindaphinda ukuziphatha ngokuzibulala, esekelwe imbali kunye neli xesha lonyango lonyango.
Izixwayiso ezibalulekileyo zeClozaril (Clozapine)
I-Clozaril ithatha izilumkiso ezintlanu ezinzulu , ezibizwa ngokuba yizilumkiso ezimnyama, malunga neziphumo ezinobungozi kunye nokusetyenziswa kwezidakamizwa. Ngenxa yezi zilumkiso, iClozaril inokumiselwa kuphela kwinkqubo ekhethekileyo eyalela ukuhanjiswa okubizwa ngokuba yi-Clozapine Risk Assessment kunye neSicwangciso soThutho (REMS). Bobabini ugqirha wakho kunye nekhemistiki yakho kufuneka abhalise kunye nale program abavelisi abayidalwe ukwenzela ukuba bayigcine kwaye bayichitha i-Clozaril. Inkqubo ye-REMS iqinisekisa ukubeka esweni kwe-WBC count kunye ne-ANC ngokubhekiselele kwishedyuli echazwe ngezantsi ngaphambi kokuba kuhanjiswe ukunikezelwa kwamachiza.
Agranulocytosis
I-Agranulocytosis yi-white cell white count count. Ekubeni iiseli zegazi ezimhlophe ziyimfuneko yokulwa nezifo, oku kungenxa yempembelelo yecala elichaphazelayo. Ngaphantsi kwe-1% yezigulane ezithatha iClozaril zinokuphuhlisa i-agranulocytosis, isiganeko esingasongela ubomi.
Ukuba uphathwe nge-clozapine, kufuneka ube nebala elisezantsi lomgca wegazi (WBC) kunye ne-neutrophil count (ANC) ngaphambi kokuba uqale iClozaril, kunye nokubalwa kwama-WBC kunye nama-ANC ngexesha lokunyanga kunye ubuncinane kwiiveki ezine ukuyeka ukunyango.
Umngcipheko wokuKhukula
Ukuxhatshazwa kuye kwadibana nokusetyenziswa kwe-clozapine.
I-daose ibonakala ibaluleke kakhulu ekubanjeni i-seizures, enokubonakala kuninzi kwii-clozapine. Ukulumka kufuneka kusetyenziswe xa ulawula i-clozapine kwizigulane ezineembali zokuthintela okanye ezinye izinto ezithintekayo. Izigulane kufuneka zicetyiswe ukuba zingabandakanyeki kuyo nayiphi na imisebenzi apho ukulahlekelwa ngokukhawuleza kokuqonda kungabangela ingozi enkulu kubo okanye kwabanye.
I-Myocarditis kunye neCardiomyopathy
I-Myocarditis ukuvuvukala kwintliziyo yesisu kunye nokukhathazeka kwentliziyo yintliziyo ekhulisiweyo. Ukuba unokuphefumula, umkhuhlane, ukhathala kakhulu okanye intlungu yesifuba ngenkathi uthatha iClozaril, qiniseka ukuba uqhagamshelane nodokotela wakho ngokukhawuleza.
Eminye Imiphumo ye-Cardiovascular and Respiratory Effects
I-Orthostatic hypotension yinto enkulu, ngokukhawuleza kwehla kwixinzelelo lwegazi ekumeni okukwenza uzive ulula okanye unesidima. I Syncope ithetha ukuphelelwa amandla.
I-Orthostatic hypotension, kunye okanye ngaphandle kwe-synncope, inokuthi iyenze nge-clozapine unyango, ingakumbi xa uqala ukuyithatha okanye i-dose yakho ishintshiwe. Ngokuqhelekileyo, oku kuya kunzulu kwaye kuhambelane nokuphefumula kunye / okanye ukuboshwa kwentliziyo. Ukuba unesifo sohudo okanye ukuhlanza okanye ezinye iimpawu zokungcola, qiniseka ukuxelela ugqirha wakho. Kwakhona, ukuba ungeyiphulaphuka i-clozaril ezimbini okanye ngaphezulu, khuluma nodokotela wakho ngaphambi kokuba uthathe umthamo wakho ozayo njengoko ungadinga ukuthatha umthamo ophantsi kwexesha.
Ukunyuka kweMpilo kubantu abakhulileyo abagulayo
Izigulane ezisebekhulile ezineengqondo ezinxulumene nomqondo wokugula ngengqondo ziphathwe ngezilwanyana zamachiza e-antipyychotic ziyiyo engozi yokufa ngokuthelekiswa ne placebo . Kwisifundo esithile, nangona iimbangela zokufa zahlukahluka, ininzi yokufa yayibonakala ibe yintliziyo ye-cardiovascular, oku kuthetha ukuba yayihlobene nokuhluleka kwentliziyo okanye ukufa ngokukhawuleza, okanye ukusuleleka kwindalo. I-Clozaril ayivunyelwanga ukunyanga izigulane ezineengqondo zengqondo.
Imithombo:
"Clozapine (Clozaril / FazaClo)." Ukusebenzisana kaZwelonke kwiMpilo yengqondo (2014).
"Clozapine." I-MedLine Plus, iThala leNcwadi likaMatriki ka-US (2015).