Izifundo zibonisa uxhumano kwezinye, kodwa kungekhona zonke, izigulane
Iingqondo ziye zatsho malunga nokuxhamla okunokwenzeka phakathi kwe-gluten kunye ne-schizophrenia iminyaka engaphezu kwamashumi amathathu. Enyanisweni, igama elithi "ubuhlanya besinkwa" lenziwe iqela leminyaka elidlulileyo ukuchaza i-schizophrenia-bekukho iingxelo zezigulane zengqondo eziphucula ngokukhawuleza xa ukutya kweemveliso zentlanzi (oko kukuthi, ubuninzi bezinto ezinokutya kwi-gluten kwizidlo zabo) azifumanekanga .
Nangona kukho iingxelo zeengxaki zezigulane ezine-schizophrenia ziphucula ngokutya okungekho gulen, kwanokuba abaphandi abasendle baqikelela ukuba kuphela ipesenteji encinci ye-schizophrenics ekugqibeleni banokuzuza ngokungenelela kokutya okunjenge-gluten-free food. Kwakhona kubalulekile ukuqaphela ukuba akukho zilungiso zokutya ezamkelweyo ngoku malunga ne-gluten ne-schizophrenia. Sekunjalo, abaphandi baqala ukujonga ukudibanisa okunzima okunokuba kukho kwi-immunology yezifo eziqhambileyo, ubuninzi be-gluten, kunye ne-schizophrenia.
I-Schizophrenia: I-Disorder Mind Disorder
I-Schizophrenia iyimeko engapheliyo, enamandla kwaye inokukhubaza ingqondo yengqondo. Ichaphazela malunga ne-1% yabantu bonke. Abantu abane-schizophrenia baxhamla kwiimpawu ezahlukeneyo, kodwa banokuva amazwi (i-hallucinations) okanye bakholelwa ukuba abantu abalawulayo okanye baceba ukulwa nabo (ukukhohlisa).
Ukulawula i-schizophrenia, oogqirha ngokubanzi balula imithi ye-antipsychotic. Inkxaso evela kwiqela lezonyango liqhelekileyo liyinxalenye ebalulekileyo yokunyamekela.
Nangona kwabanye abantu isifo singakwazi ukulawulwa ngokwaneleyo ukuba sibe ngamalungu oluntu oluthileyo, abanye abane-schizophrenia bayakhubazeka kakhulu.
Nangona abaninzi abantu abane-schizophrenia bengabundlobongela kwabanye, malunga ne-10% ekugqibeleni bayazibulala.
I-Wheat Gluten: I-Schizophrenia inokwenzeka
Emuva ngo-1976, abaphandi bapapasha isifundo kwiSayensi becacisa ukuba iprotheni ye-gluten ingqolowa ibangele okanye ikhuthaze i-schizophrenia. "I-Schizophrenics igcinwe kwi-cereal-free-free and free-milk-free diet and receiving a treatment optimal (ie, i-antipsychotic drugs] ibonakalise ukuphazanyiswa okanye ukuguqulwa kwenkqubela yabo yokwelapha ngethuba lobunzima beengqolowa". . "Emva kokupheliswa komngeni we-gluten, inkqubo yokuphuculwa yabuyiselwa kwakhona. Iimpembelelo ezibonakalayo zibonakala ngathi ngenxa ye-schizophrenia eyinqobo-okukhuthaza ukolweni wengqolowa."
Njengoko iminyaka ihamba, iziphumo ezininzi zijonge kwiziphumo ezibangelwa yi-gluten kwi-schizophrenia, kunye neziphumo ezidibeneyo. Uphando olupapashwe ngo-1981 lwagcina izigulane ezilishumi ezisibhozo ze-schizophrenia kwi-gluten-free-free-free-food-free and then challenged them with wheat gluten kwiiveki ezintlanu. Uphononongo alufumani nantlukwano kwimpawu zabo ze-schizophrenia xa zidla i-gluten.
Nangona kunjalo, ngovavanyo luka-1986, abaphandi bafunda izigulane ezingama-24, ngokukodwa abantu abane-schizophrenia, kwi-gluten-free diet, kwaye bafumanisa ukuba ababini babantu baphucula ngexesha le-gluten-free and relapsed when food gliten-containing containing.
Uphando olutshanje luye lwaphawula le mpembelelo yokutya okungekho i-gluten kwi-subset encinci yezigulane ezine-schizophrenia kwaye ikhuthaze izifundo eziphambili ze-epidemiology kunye nezilingo zeklinikhi ukucacisa ukuba kutheni le nto yenzeka kwaye iziphi izigulana zakwa-schizophrenia ziya kuzuza. Uhlaziyo olunzulu lweencwadi zonyango kwiingxaki ezinxulumene ne-gluten kunye neengxaki eziphazamisekileyo zengqondo ukuba abantu abanesifo esingenayo okanye ubuninzi be-gluten babenokuba "nomngcipheko omncinci we-schizophrenia kunye neengxaki zengqondo."
I-Gluten Antibodies echaphazelekayo
Abantu abanesifo esingapheliyo sesifo (ie, abo badla ukutya okuqhelekileyo kunye ne-gluten-containing containing foods) babonisa amanqanaba aphezulu e-antibodies, ezibandakanya i-tTG-IgA kunye ne-EMA-IgA, xa kuhlolwa iimvavanyo zegazi.
Ezi mvavanyo zizodwa kumonakalo wamathumbu emathunjini atholakala ngenxa ye-gluten kwisifo se-celiac.
Abanye abantu abane-schizophrenia, okwangoku, babonisa amanqanaba aphezulu amanye ama-antibodies ukuba abe ne-gluten-ngokukodwa i-AGA-IgG kunye ne-AGA-IgA antibodies. Ngokomzekelo, uphando oluthile olujonge izigulane eziyi-1,401 ze-schizophrenia zifumene i-23% zazo zilingenele ukuya kumazinga aphezulu ase-AGA-IgA.
I-AGA-IgA kunye ne-AGA-IgG iintsholongwane zibhekiselwe ngaphantsi kwezifo ze-celiac-zibonisa ukuba isistim somzimba sokuzivikela komzimba ku-gluten siyaqhubeka, kodwa kungekhona isifo esinqabileyo esitholakalayo kwisifo se-celiac.
Enyanisweni, isifundo esakhangela abantu abanezifo eziqhekezayo kunye nabantu abane-schizophrenia ngokwahlukileyo bafumanisa ukuba amaqela amabini abonakala ephendula kwiindawo ezahlukileyo zeprotheni ye-gluten, ebonisa ukuba nayiphi na indlela yokuphendula umzimba kwi gluten kwi-schizophrenia eyahlukileyo neyesi sifo se-celiac, kwaye lizimeleyo kunoma yimuphi umonakalo wamathumbu emathunjini.
Abaphengululi baphetha ngokuthi, "iziphumo zethu zityhila iimpendulo zokuzivikela komzimba kwi-gluten kubantu abane-schizophrenia ehluke ngokucacileyo nakwimeko yesifo se-caliphrenia."
ILizwi
Nangona kungavunyelwanga ngokubanzi kwintsimi yempilo yengqondo, iYunivesithi yaseMadrid Centre kwisiCwangciso soPhando lweCeliac uDkt. Alessio Fasano ithi i-subset engabonakaliyo yabantu abaneengxaki ezithile zengqondo, kubandakanywa ne-schizophrenia kunye ne-autism, zibonakala ziphucula okanye ziphinde zibuye ekudleni okungenakudla, kungakhathaliseki ukuba abanaso isifo se-celiac.
Nangona kunjalo, akukho nxaxheba okwamkelekileyo ukuvavanya ubuninzi be-gluten. Ayikho indlela eyamkelweyo yokufumanisa ukuba isiguli schizophrenia siya kuzuza kwi-gluten-free food; Izilingo ze-AGA-IgA kunye ne-AGA-IgG azibonakali ukuthabatha wonke umntu onesimo. Abaphandi okwamanje bazama ukuchonga i-biomarker ethile engakhokelela ekuvavanyweni kwezokwelapha eziza kubonakalisa abaninzi okanye bonke abantu abanobunene be-gluten, kuquka abo abane-schizophrenia. Kuze kubekho uphando olongezelelweyo lwenziwe, ootitshala bezonyango abacebisi ukuba bangena-gluten kwiinzame zokunceda i-schizophrenia.
Imithombo:
> Brietzke E. et al. Izifo ezinxulumene neGluten kunye neengxaki eziphambili zeengqondo: Ukuhlaziywa ngokubanzi. I-neuroscience kunye neengcebiso ze-Biobehavioral . 2018 Jan; 84: 368-375.
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