I-bipolar mood ithala leencwadi
I-Topamax (i-topiramate yesi-generic) yipilisi ye-anticonvulsant evunyiweyo yi-US Food and Drug Administration (FDA) ukuze isetyenziswe ekuphatheni i-stpile and headaches. Nangona i-Topamax ibe kwaye iqhubeka isetyenziselwa ukusetyenziswa kwonyango lwe-bipolar disorder , akuyiyo i-FDA evunyelwe ukusetyenziswa. Nangona kunjalo, oogqirha abaninzi banikezela i- Topamax kwi-ileyile ye-bipolar disorder.
Iziphumo ezibini zephando lwezonyango zivalelana nazo zifunyenwe nezifundo zakudala, zifumanise ukuba i-Topamax iphumelele ngentsholongwane ye- bipolar xa isetyenziswe njengesongezelelo kwezinye izimo ezizinzileyo kodwa zingasebenzi kakuhle xa zisetyenziselwa yodwa.
I-Topamax idla ngokuphambuka njenge-Topomax.
I-Topamax iza kwiipilisi kunye neefomsile ezingavulwa kwaye zifafazwe ekutheni ukutya okunotshani ezifana ne-pudding, yogurt, i-ayisikrikhi kunye nokunye ukutya okungafuneki ukuhlafuna. Ukuba usebenzisa i-Topamax iifomfle zokufafaza, kufuneka udle ukutya konke ukutya ngokukhawuleza; ungayigcinanga kamva.
Izilumkiso ezinkulu kwi-Topamax
- Metabolic Acidosis. Ukusetyenziswa kwe-Topamax kuhambelana nale meko, apho igazi liba lukhuni kakhulu. Kukho umngcipheko ophezulu wokuphucula i-acidosis yamagciwane kwizigulana zezilwanyana eziphantsi kwe-15 nangaphantsi. Iimpawu ziphefumula ngokukhawuleza (ukuxhatshazwa kwe-hyperventilation), ukukhathala, ukwenqaba ukutya, kunye nokunyuka. Le meko ingaba yinto enzulu xa ingaphathwa. Iilebuli evunyiweyo ye-Topamax icebisa ukulinganiswa kwe-acidity yegazi xa uqala unyango kunye nokuhlolwa kwexesha.
- Glaucoma. I-syndrome equlethwe ngumbono osondeleyo (i-myopia) ehambelana nesifo sengqondo esibizwa ngokuba yi-glaucoma yokuvalwa kwimizuzu yesibini eyenziwe kwizigulane zisebenzisa i-Topamax. Iimpawu zivame ukuvela kwinyanga yokuqalisa unyango lwe-Topamax kwaye zibandakanya ukuphazamiseka ngokukhawuleza kombono, intlungu yeso, kunye namaxesha obomvu okanye abafundi abaxutywa ngokubanzi. Ukuba ufumana nayiphi na le mpawu, qha ga mshelana nodokotela ngokukhawuleza. Ukuba unogqirha awunayo, ungaqhagamshelana ne-ophthalmologist.
- Ukunyuka kweNtlungu kunye neFaver. Oku kuye kwaxelwa kakhulu kubantwana, kwaye izigulane kufuneka zibekwe iliso ngenxa yale mpawu, ingakumbi kwishushu eshushu. Ngenxa yokuba amaninzi amanqaku anqamlekileyo kunye nokugqithiseleyo angenza umntu abe neengxaki zokutshisa, qiniseka ukuba ugqirha kunye nekhemistiya bayazi zonke iziyobisi isigulane esithathayo.
- Ungayeki ukuthatha i-Topamax ngokukhawuleza. Kukho umngcipheko okhulayo wokubanjelwa ukuba oko kwenziwa.
- Iintsimbi zeeNtliziyo. Kukho umngcipheko okhulayo wokuba ngamatye eentso xa uthatha i-Topamax. Qiniseka ukuba uphuze amanzi amaninzi.
- Ukukhubazeka kwamaReal. Ekubeni i-Topamax isuswe emzimbeni ngeentso, i-dosage ingadinga ukutshintshwa kwizigulane ezinokukhubazeka kwe-renal, ngakumbi kulabo abaneminyaka engama-65 nangaphezulu.
Ukusebenzisana kwezidakamizwa ze-Topamax
- Ezinye iAnticonvulsants. Kwiimvavanyo zeclini, ukuhlanganisa iTegretol (carbamazepine) ne-Topamax kubangele ukuhla kwe-40% kwinqanaba le-Topamax. NgeLamictal (lamotrigine), izinga le-Topamax landa nge-15%, kwaye kunye ne- Depakote (i-valproic acid), zombini iziphumo zamachiza zanciphisa 11-14%. Nangona kunjalo, i-Topamax ne-Depakote edibeneyo yenza ingozi kwimeko ebizwa ngokuba yi-hyperammonemic encephalopathy. Iimpawu ziguqulwa ngokukodwa kwinqanaba lokuqonda kunye / okanye umsebenzi wokuqonda kunye nokuhlanza okanye ukuhlanza.
- Ulwaphulo lomlomo. Kukho umngcipheko wokunciphisa ukhuselo lokukhusela nokuphulukana nokuphuma kwamanzi xa uthatha i-Topamax kunye ne-contraceptive ene-estrogen.
Kukho intsebenziswano yezinye iziyobisi. Funda ngokucacileyo ulwazi ngokuphindaphindiweyo, qinisekisa ukuba ugqirha wakho kunye nekhemistiya bayazi zonke ezinye imishanguzo, zombini emiselweyo kunye ne-counter-counter-counter, ukuba uthatha.
I-Topamax kunye nokukhulelwa / Ukuncelisa isisu
Izifundo zezilwanyana zibonise ingozi enkulu kumntwana osuka kwi-Topamax, kwaye kubantu, kukho ingozi enkulu yokuzalwa kweziphene ezibizwa ngokuba yimicenge yomlomo. Kufuneka ukuba udibanise ugqirha wakho wokumisela ukuba ukhulelwe okanye uceba ukukhulelwa.
I-Topamax kufuneka isetyenziswe ngexesha lokukhulelwa kuphela ukuba inzuzo enokuthi iphakame ingozi ebantwini abangakazalwa. Nangona kungekho zifundo ezilawulwayo kwi-secamtion ye-Topamax ebisi, ubungqina bubonisa ukuba lufihliwe ngokubanzi, kwaye kwakhona, ulinganisa izibonelelo kunye nobungozi ngokucophelela.
Iimpembelelo eziqhelekileyo ze-Topamax ne-Topiramate
Impembelelo echaphazelekayo yecandelo le-Topamax yi-paresthesia okanye i-tingling yemida. Imiphumo eyingozi eyenziwa ngabantu abaninzi ibangela ukuba abantu bayeke ukuvavanywa kwezilingo bebuthongo kunye nokukhathala. Iingxelo zogxininiso zandiswe kumaqondo aphezulu. Ekubeni kunakho ukuzondloba, ukudideka, nobunzima bokugxila, ungaqhubi okanye usebenzise umatshini de uze wazi ukuba usabela njani kule nyango.
Ezinye iziphumo eziqhelekileyo ziquka:
- Ukuphelelwa kwesidlo
- Ukuhla ukusinda
- Ubunzima bokukhumbula, ukugxininisa okanye ukuqwalasela
- Kubantwana, isifo sokuphefumula esiphakamileyo
I-Topamax kunye nokulahlekelwa kwesisindo
Kuninzi okwenziwe malunga nokulahlekelwa ubunzima kwi-Topamax. Kwizilingo zeklinikhi, ukwehla kwesisindo kwenzeke kwi-21% yezifundo, ngokuqhelekileyo ngaphantsi kwelo, kwaye kwakuxhomekeke kumthamo, kunye nenani elikhulu labantu abalahlekelwa ubunzima kwi-400mg ngosuku. Ekubeni umngcipheko weempembelelo zonyango ukwanda ngeqondo eliphezulu, umntu ngamnye kufuneka ahlolisise impendulo yakhe kwisichengululo.
> Imithombo:
Kushner, SF, Khan, A., Lane, R., Olson, WH (2006). "I-Topiramate Monotherapy ekulawuleni i-Acute Mania: Iziphumo zeeMvavanyo eziPhezulu ezine-Blind Placebo." http://www.ncbi.nlm.nih.gov/entrez/...&list_uids=16411977.
McIntyre, RS, Riccardelli, R., Binder, C., Kusumakar, V. (2005). "I-Topiramate ene-Label evulekileyo kwi-Treatment of Disability Bipolar Disorder." http: //www.ncbi.nlm.nih.gov/entrez /...& list_uids = 16086539 ....
IMedialine Plus Medical Encyclopedia. (2005). "Glaucoma." https://medlineplus.gov/ency/article/001620.htm.
IMedialine Plus Medical Encyclopedia. (2006). "I-Metabolic Acidosis." https://medlineplus.gov/ency/article/000335.htm.
US Food and Drug Administration. (2005). "I-FDA I-Text Labeling Text Approved 6/29/05 ye-Topamax® (topiramate) Iipilisi kunye ne-Topamax® (i-Topiramate Capsules).