Umonakalo wobungozi bomsebenzisi weziyobisi ekugqibeleni ukugqithiselwa njengobungakanani beminyaka yobudala 17
Iimviwo ze postmortem ezingama-34 abatsha abaye bafa ngethuba elidala baye banikela abaphandi ithuba lokungabonakalisi kwingozi ekusebenziseni iziyobisi zentyaza enokwenza kubomi babasebenzisi.
Kuphando olupapashwe kwi- Neuropathology ne-Applied Neurobiology, abaphandi bavavanya ubuchopho be- heroine abangama-34 kunye nabasebenzisi be- methadone abafa kwinqanaba eliphakathi kweminyaka engama-26.
Abanye babo bafa ngo-17 Baqhathanisa ubuchopho babo kwiibinzana ezingama-16 abatsha abafayo kodwa bengabasebenzisi beziyobisi.
Uviwo lufumanise ukuba abahlukumezi beziyobisi babezihlandlo eziphindwe kathathu ukuba babe nomonakalo wengqondo kunabo abangasebenzisi iziyobisi. Ubungqina bentsha abasebenzisi abasebenzisa iziyobisi babonakala banjengabantu abadala kakhulu kunye nomonakalo ofana nomntu onesifo se-Alzheimer's disease.
Iimpawu zeNerve eziMonakalo kuMsebenzisi weziyobisi
Inzululwazi kwiYunivesithi yase-Edinburgh yafunda ubuchopho bomntu oshonile abaxhaphaza izidakamizwa ze-heroin kunye ne- methadone kwaye bawafanisa nobuchopho babantu abancinci abangengabasebenzisi beziyobisi.
Iisensi zeentsimbi ezonakalisiweyo zazingekho kwimimandla yengqondo echaphazelekayo ekufundeni, kwimemori, nangentlalo enempilo, kwaye yayifana nomonakalo ofumaneka kwiindawo zokuqala zesifo se-Alzheimer.
Uphononongo lwethu lubonisa ubungqina bengozi yokonakalisa ingqondo ehambelana ne-heroin kunye nokusetyenziswa kwe-methadone, enokuba yinto ephakamileyo kuncinane xa abantu banakho ukufumana umkhwa. "- Unobhala-mbhali waseJean Bell uProfesa we-Neuropathology.
"Sifumene ukuba ubuchopho bala bantu abancinci beziyobisi babonisa amanqanaba aphezulu aphezulu aphethwe ngumonakalo wengqondo."
"Kwisifundo esedlule, safumanisa ukuba ukusetyenziswa kakubi kweziyobisi kubangela ukuvuvukala kwezinga eliphantsi kwengqondo. Kuthathwe ndawonye, ezo zifundo ezimbini zibonisa ukuba ukusetyenziswa kakubi kwe-opiate kunokuxhatshazwa ukuguga kwangaphambili kwengqondo," kusho uBell.
IHerinin kunye neMethadone Yenza umonakalo
Umyinge oseminyaka kula maqela amabini kwisifundo bekuyiminyaka engama-26 kuphela kwaye waquka abahlukumezi beziyobisi njengabantwana abashumi elinama-17.
"Iprotheni yeTau, efanelekileyo kwindlela yokunxibelelana kunye nezothutho ngaphakathi kweeseli zengqondo, yayingenakunqandwa kwamanye amaseli, eyenza umonakalo weselonda kunye nokufa kwiindawo ezikhethiweyo zobuchopho," kubhali babika. "Ezinye iiseli zesibindi zabonisa ukuqokelela kweprotheni ye-amyloid ngaphambili, ebonisa ukuba ukuthuthwa kweprotheni kuye kwaphazamiseka kwaye imisebenzi yamaseli yentsholongwane yachaphazeleka."
Ukulimala kweeNgcini zeNerve
"Olu hlolo lubonisa ukuba ukusetyenziswa kakubi kweziyobisi kungakhokelela ekwakhiweni kweeprotheni ezibangelwa umonakalo omkhulu wentsholongwane kunye nokufa kwiindawo ezibalulekileyo zobuchopho. Oku kuxhalabisa kakhulu kuba kukho izibonakaliso ezinamandla zokusetyenziswa kweziyobisi, ngakumbi i-opiates njenge heroin kunye methadone, uye waqhubeka nokunyuka kwiminyaka yamuva , "utsho uProfesa Bell.
"Abaxhaphazi beziyobisi esasizibukeleyo kulesi sifundo badabukisayo bafa beselula, kodwa baninzi abanye abangaqapheliyo imiphumo yesikhathi eside ezi ziza kubangela izidakamizwa."