Usetyenziso lweCocaine oluSigxina lungenza iinguqu kwiBrain
Abasebenzisi abaninzi bexesha elide be-cocaine baxinezeleka. Iirhafu zokudakumba ezichazwe kwi- cocaine abahlukumezi abangapheliyo ziphezulu kakhulu kunabantu bonke.
Ukuzama ukucacisa ukuba kutheni abasebenzisi be-cocaine baziva bexinezelekile kunye nezinye iingxaki, izazinzulu zikholelwa ukuba zidibene nomonakalo owenziwe yizilwanyana kwiintsholongwane zobuchopho ezenza abasebenzisi bazive bephezulu xa benza i-cocaine.
Ukuphazamisa okanye ukubulala ezikhoyo iingqungquthela zengqondo ezikunceda umsebenzisi uzive ukuzonwabisa, unokuziphendulela kwizinga eliphezulu lokudandatheka phakathi kwabahlukumezi be-cocaine abangapheliyo , abaphandi bathi.
I-Dopamine Neurons iphazamisekile
Xa i-cocaine isetyenziselwa ukwandisa izinga le-dopamine kwintliziyo, ukudala ukuphakama kwabasebenzisi, kodwa ukusetyenziswa ixesha elide kweziyobisi kunciphisa amanqanaba e-dopamine, okwenza kube nzima ukuba umsebenzisi abe nemvakalelo emihle.
"Olu bubungqina obucacileyo ukuza kuthi namhlanje i-neurons cocaine idibanisa kwaye ayithandi kwaye iphazamiseka yimiphumo yeziyobisi," kusho uKarley Little, MD, uprofesa onxulumene nokugula kwengqondo kwiYunivesithi yaseMichigan Medical School kunye nomphathi U-Ann Arbor weeNqila zezoLimo zeZiko lezeMpilo I-Neuropharmacology yeLayibrari. "Imibuzo esibhekene nayo ngoku: Ngaba iiseli zilala okanye zonakaliswe, ingumphumo onokuguqulwa okanye osisigxina, kwaye uyakukhusela?"
Ixesha elide labasebenzisi beCocaine bafundiswa
Abancinci kunye nabalingane bafunda iisampuli zengqondo zengqondo ezifunyenwe ngexesha lolawulo lwamaxesha angama-35 abasebenzisi be- cocaine kunye nabangewona abasebenzisi abangama-35. Bahlalutye izicubu ze-dopamine kunye neprotheni i-VMAT2, efumaneka kwi-dopamine yokuthutha.
Iisampuli okanye iisampuli ze-serum nazo zahlaziywa ngenxa yobukho be-cocaine, i-opioids, i-anti-depressants, kunye neyeza-antipsychotic.
Umntu osondelene nomntu ngamnye waxoxwa ngaye malunga nokusetyenziswa kakubi kweziyobisi, ukusetyenziswa kotywala, kunye neempawu zobuntu kunye neengxaki zengqondo.
Ichaza iCocaine yokuSula iMpawu
Abaphandi bafumene ukuba abasebenzisi be-cocaine baneengcipheko ezincinci ze-dopamine kunye ne-VMAT2 ebuchosheni babo kunokuba bengabasebenzisi. Ukongezelela, abasebenzisi be-cocaine abanengxaki yokudakumba babenamazinga aphantsi e-VMAT2 kunabo abazange bacinezelekile.
"Idatha yethu inikezela kakhulu imveliso ye-cocaine ye-cocaine." Iincwadi ezikhoyo zibonisa ukuba umsebenzisi we- cocaine ogxininisekile uya kuba neengxaki ezininzi zokugcina intsapho kunye nomsebenzi, kuba nexesha elinzima ukuyeka, kunokwenzeka ukuba aphelelwe unyango, kwaye kunokwenzeka ukuba uzibulale, "kusho uNcinci.
ICocaine iguqula ubuchopho
Abancinci kunye nabalingane babengaqinisekanga ukuba iiseli ze-dopamine zatshatyalaliswe okanye zitshatyalaliswa ngokusetyenziswa kwe-cocaine, kwaye ukuba utshintsho olunjalo luya kuguqulwa.
"Singabona imbangela yesilingo somzamo wokulawula inkqubo ye-dopamine ekuphenduleni ukusetyenziswa kwe-cocaine, ukuzama ukunciphisa inani le-dopamine ekhutshwe ngokunciphisa amandla okuyiqokelela kwi-vesicle," kuthethwa kancinci. "Kodwa sinokubona umonakalo wangempela okanye ukufa kwi- dopamine neurons .
Ngandlela-thile, oku kukugqamisa ukuhlukana kwezi neuron kwaye kubonisa umjikelezo onobuqhetseba obunokusetyenziswa kwecocaine. "
Imizamo engakumbi xa kucaciswa iziphumo ezibangelwa yi-cocaine kwiiseli zengqondo zinokunceda ekuphuhlisweni kwamanyathelo angenelelo kunye ne-pharmacotherapies, abaphandi bacebisa.
Uphononongo lwaxhaswa ngemali kwiNkcazo kaZwelonke yokuSetyenziswa kakubi kweziyobisi.
Imithombo:
Ncinane, KY, et al. "Ukulahlekelwa kweprotheni ye-Striatal Vesicular Monoamine Transporter (VMAT2) kwi-Human Cocaine Users." I-American Journal ye-Psychiatry ngoJanuwari 2003
UMilne, D. "I-Cocaine ibonakala kwiDopamine Neurons ye-Damage Brain." Iingxelo zeeNgqondo zikaFebruwari 2003