Kwimemori yakhe ye- Skywriting, umama we- NBC-TV uJane Pauley wachaza ukuba unengxaki yokuphazamiseka kwengqondo. Ukugula kubonakala, uthi, xa enikwe i-steroids kwimeko yemihlathi. Esi sityhilelo sigxile kwingqalelo phakathi kobudlelwane phakathi kwe-steroids kunye nokudakumba komntu.
U-Pauley ubhala, kwingxenye yencwadi yakhe yachithwa ngo-Agasti 20, 2004, abantu, ukuba wafumana i-hypomania emva kokulawulwa kokuqala kwe-steroids kwimisundu yakhe kunye nokudakumba kwesibini.
Ukudakumba kwakunzima ngokwaneleyo kangangokuba umyalelo wokunyanzela umthamo ophantsi owamiselwa kuye, waza wabuya waba ngumbuso odibeneyo kunye nebhayisikili ngokukhawuleza. Ugqirha wakhe wachaza, uthi, ukuba i-antidepressant "ivule unobungqina obunokubakho ubunzima bokubandezeleka kwengqondo." Kodwa eqinisweni, ukuguquka kwemizwelo kwakuqale ngaphambi koku - kunye ne-steroids. Wayebhedlele esibhedlele kwaye wazinza kwi-lithium.
Ziziphi i-Steroids?
Ngokutsho kwe-PDR Medical Dictionary, igama elithi "steroid" lisebenza "kwintsapho enkulu yamachiza, equkethe amahomoni amaninzi, amaqumrhu omzimba kunye namachiza." Kwakhona "ukwenziwa kobugcisa beemveliso ezihlobene ngokuthe ngqo kwi-steroids, njenge-sterols, i-bile acids, i-glycosides ye-cardiac, i-androgens, i-estrogens, i-corticosteroids, kunye ne-precursors ye-vitamini D" (2000). Ngokuqinisekileyo akudingekile ukuba wazi ukuba ziphi ezo zonke - kodwa ngokucacileyo, i-body chemistry kunye nemisebenzi eyenziwe, elawulwa yiyo, okanye enxulumene nalezi zinto zikhulu.
Kukhuselekile ukuthetha ukuba akukho nto eyenzekayo emzimbeni ngaphandle kokubandakanyeka kwe-steroid. Ngenxa yoko, akufanele kusimangalise ukuba i-steroids elawulwayo ingabangela iziphumo zecala, apho "i-steroid psychosis" yinye isiphumo esibhaliweyo. "I-steroid psychosis - okanye ngaphezulu ngokufanelekileyo, imiphumo yesifo sengqondo ye-steroid-ingabangela ukuphazamiseka kwengqondo (umz., Ukuxinezeleka, imania, okanye zombini), kunye ne-delirium" (i-Cortlandt Letters, Disemba 2001).
I-Anabolic steroids, esetyenziswe isizukulwana sabathatyathi sokwakha isisulu kunye nobuninzi kude kubekho iziphumo ezinobungozi ezininzi ezibonakalayo ukuba ezininzi zezi zi yobisi zivaliwe, zinokubangela ukuba i-mania ibenze. I-corticosteroids, eyayiza kubandakanya iyeza elinqunyiwe kwimingxuma kaJane Pauley, ibonwe ukuba ibangele iimpawu zengqondo kwizifundo. Ngokwe-"Steroid-Distuced Minding Disturbances" (i-Perry & Lund, yahlaziywa ngo-2004), ababhali babika ngophando luka-1972 yiProgram yeBock Collaborative Surveillance Programme apho izigulane ezithatha izilwanyana ezahlukeneyo zePrednisone (i-corticosteroid), ukusuka phezulu ukuya phezulu, iziganeko eziqhubekayo zokuphazamiseka kwengqondo: i-psychosis, imania, kunye nokudandatheka. Eli phepha lithetha ukuba ngelixa i-mania isabela ngokuqhelekileyo ekusebenziseni i-steroids, ukuxinezeleka kudla ngokubangela ukuhoxiswa kwe-steroid.
Ezinye ze-medical steroids eziqhelekileyo kunye nokusetyenziswa kwazo
Amanye amagama aqhelekileyo ayaziwa ngama-corticosteroids aquka:
- Cortisone kunye ne-Hydrocortisone
- I-Flonase® (i-fluticasone propionate nasal spray)
- Lanacort® (i-hydrocortisone topical)
- Prednisone
- I-Nasonex® (i-mometasone nasal)
Kwaye abanye abaninzi bekuya kuba ngaphaya kweli nqaku ukuzama ukubiza uninzi lwabo.
I-Corticosteroids isetyenziswe kunyango lweemeko ezahlukeneyo zonyango kuquka:
- Isifuba
- Emphysema
- Isifo sikaCrohn
- Bursitis
- Tendinitis
- Ulcerative colitis
- Iimbuzi
- Inambuzane iyabetha
- Ukunyuka kwamanzi
- Eczema
- Psoriasis
DHEA
Ukuthengiswa kwamanye ama-hormone e-steroid, i-DHEA, sele iphuma emininzi kwindawo yoluntu-uphando - omnye umphandi wabiza ngokuthi "ioli yenyoka ye-90s." Ingxelo kaMarkowitz, Carson, noJackson (1999), "... (iDHEA) iphakathi kwe-steroid enkulu kakhulu emzimbeni womntu kwaye ibonakala inemisebenzi eyahlukeneyo yezinto eziphilayo. Ukuphakanyiswa kwayo kwangoko kunye nokufumaneka njengento engaphezulu kwee-counter kwintlalo jikelele kubangele ukusetyenziswa ngokubanzi.
Akukho nto eyaziwayo malunga nemiphumo emibi ye-DHEA xa isetyenziswe kwisigxina okanye esingapheliyo. Sichaza ityala le-mania kumntu osekhulile wamkela kwisibonelelo sethu sengqondo ngokungenanto yangaphambili yomntu okanye yentsapho imbali ye-bipolar disorder eyabonakala ihambelana nokusetyenziswa kweDHEA yakutshanje. Isigulane sasiqalise i-DHEA seenyanga ezintandathu ngaphambi kokungeniswa kwaye sithatha i-200-300 mg / ngosuku ngexesha lokubonisa. "Ngelishwa, abavelisi abahlukahlukeneyo bathi i-DHEA" imangaliso "okanye umthombo wobutsha. .
Ngokutsho kwengqondo yengqondo uDkt Henry Lahmeyer, i-steroids engasetyenziswanga yodwa ayinakwenzeka ukuba ibangele nayiphi na ingxaki yokuphazamiseka kwengqondo; Kunoko, kukulawula okuqhubekayo kunye nokuqhubekayo kwe-steroids apho iziphumo zengqondo zengqondo zingabonwa. Kwimeko yePawley, wayethatha i-steroid kwiinyanga ezintlanu ngaphambi kokuba uguquko lwengqondo luqale.
Ukukhangela iincwadi eziphathekayo zezokwelapha nezengqondo zivelisa iinjongo zezifundo ezithile, njengalezo zichazwe ngaphambili, ezibonisa ukuba ukusetyenziswa kwe-steroid kunakho iziganeko zokuphazamiseka kwengqondo. Yaye ngelixa uphando alukabonakali isizathu esicacileyo sale matyala, ezinye iziphumo ziqala ukukhanyisa lo mbuzo. U-Wood et al (2004) ingxelo yokuba uphando malunga neerati, ukuxinezeleka okungapheliyo, kunye nokulawulwa kwe-hormone ye-corticosterone yokucindezeleka, kubangela utshintsho olwenziwe kwimibutho ye-neurons kwi-hippocampus, inxalenye yengqondo. Ezi zinguqu zihamba kunye neenguqu zokuziphatha.
Okwangoku akukho kophando olunika ubungqina bokuthi i-steroids inokubangela ukungazinzi kwengqondo okanye ixesha lokugula. Ingram noHimeman (2003) inqaku, "Iingxelo ezipapashiweyo zichaza ukubonakala kweempawu zengqondo kunye nokusetyenziswa kwe-corticosteroid. Nangona indlela engacacanga, ukuphendula kuthathe ukuguqulwa ngokunciphisa umthamo okanye ukucinywa kwe-corticosteroid. yenziwe, utyando olunjalo lubandakanya unyango lwe-antipsychotic. " Uphando lwe-Wood et al (2004) luyabonisa ukuba ezinye iinguqu ezichazwe kwi-hippocampus zinokuthintelwa "ngokukhetha unyango oluchanekileyo kunye ne-anticonvulsant unyango lweziyobisi." Abaphandi bahlola ukusetyenziswa kwe-lithium kule nxaxheba kwaye bafumanisa ukuba unyango lwexesha elide ne-lithium lunokukhusela i-hippocampus. Ukuqhubela phambili kweli nqanaba lophando kwixesha elizayo lithatha isithembiso sokuqonda okungcono kwimiphumo yesifo sengqondo kunye neendlela ezisemva kokusebenza kweziyobisi ekwenzeni i-bipolar disorder.
> Imithombo
> Iforamu yeCortlandt. Ngaba izigulane ze-bipolar zisengozini enkulu nge-steroids?
> Ingram, DG, &. Hagemann, TM (2003). I-Promethazine unyango lwe-psychosis-induced psychosis kumntwana. I-Annals ye-Pharmacotherapy. Dec 01: 37: 1036-1039.
> Markowitz, JS, Carson, WH, & Jackson, CW Inokwenzeka > i-dihydroepiandrosterone > -iyenziwe imania. Biological Psychiatry, 45, 241-242.
> I- PDR Dictionary Medical. Baltimore, Maryland: Lippincott Williams & Williams. 2000.
> Perry, Paul, > Ph.D >, BCPP, kunye noBrian C. Lund, Pharm.D. Ukuphazamiseka Kweengqondo ze-Steroid. (Uhlaziywa 2004).
> I-Wood, GE, Young, LT, Reagan, LP, Chen, B., & McEwen, BS "Ukunyaniseka kwendlela yokunyamezela ingxaki kwi-hippocampus: Ukuthintela unyango lwe-lithium." Iinkqubo zeSizwe seSizwe soNzululwazi wase-United States yaseMerika. Mar 04: 101: 3973-3978.