Ababhemayo banalo lonke i-Total Sperm Count
Ukuxhaphaka kwegciwane kusetshenziswe phakathi kwendoda yokuzalwa komntwana akuzange kuphakame, ngelixa i-man factor infertility iyanda. Abaphandi bakholelwa ukuba ukusasazeka kwe-marijuana yezokwelapha kunye nezokuzonwabisa kwi-US kunokubangela ukuba kunyuke kwindoda engapheliyo.
Izifundo eziliqela ziye zaxhamla ukusetyenziswa kwegciwane kunye nokungabikho kwamadoda kodwa ukusetyenziswa kweziyobisi kuthintela ukungabikho kwempilo kuye kwabakho ngezizathu ezahlukeneyo.
Olunye uphando lufumanise ukuba amadoda abhema umgqomo kaninzi anesiphelo esincinci se-seminal fluid, isibalo esiphezulu sesibalo sesidoda kunye nesidoda sawo siziphatha ngendlela engavumelekanga. Zonke ezi zinto zingathintela kakhulu ukuzala.
IYunivesithi yaseBuffalo isifundo sokuqala ukuhlola iimiphumo zogubhu kwi-behavioral yokubhukuda kwe-sperm evela kwabashushu be-marijuana nokuthelekisa iziphumo kunye nesidoda esivela kumadoda eqinisekisiweyo. I-Marijuana iqulethe izidakamizwa ze-cannabinoid THC (i-tetrahydrocannabinol), ikhemikhali yayo ephambili ye-psychoactive, kunye nezinye i-cannabinoids.
Isibindi Sokubhukuda Ngokukhawuleza, Ngokukhawuleza Kwangoko
"Umgca weyona nto, izithako ezisebenzayo zentshonalanga zenza into ebuncwaneni, kwaye iinombolo zibhekiselele ekungabikho komntwana," kusho uLani J. Burkman, Ph.D., umbhali ohamba phambili kwisifundo.
"Asiyazi kakuhle into eyenzekayo ekutshintsheni ukusebenza kwesidoda," kusho uBurkman, "kodwa sicinga ukuba enye yezinto ezimbini: i-THC inokubangela ixesha elingalunganga lomsebenzi wesilisa ngokuvuselela ngokuthe ngqo, okanye kunokungaphaya kwemvelo iindlela.
Kungakhathaliseki ukuba yintoni imbangela, inambuzane ibhukuda ngokukhawuleza kakhulu. "
Utshintsho kwi-Sperm Enzyme Cap
Lo mzekelo ongekho mthethweni uye wadibaniswa nokungafumaneki kwezinye izifundo, wathi.
Ucwaningo lweBuffalo lufumene kwi-laboratory ye-andrology lubonise ukuba i-sperm yomntu evezwe kumanqanaba aphakamileyo ye-THC ibonakalisa utshintsho olungavumelekanga kwi-cap enzyme ye-sperm, ebizwa ngokuba yi-acrosome.
Xa abaphandi bavavanya i-anandamide equals-synthetic equation - i-fatty acid e-neurotransmitter ebalulekileyo-kwi-sperm yomntu, iipatheni eziqhelekileyo zokubhukuda zatshintshile kwaye i-sperm ibonisa amandla okunciphisa ukuxhamla kwiqanda ngaphambi kokuchumisa.
Uvavanyo lweSperm Count
UBurman kunye nabo basebenzisana nabo bafumana umkhuhlane we-seminal kusuka ku-22 baqinisekisa ukutshaya i-mariju kwaye bafaka iisampuli kwiimvavanyo ezahlukeneyo. Izifundo ezivolontiya zazisa ukutshaya i-marijuana malunga nezihlandlo ezili-14 ngeveki, kwaye kumyinge wama-5.1 iminyaka.
Amanani okulawula atholakala kumadoda angama-59 avuthileyo ayenayo ukukhulelwa. Bonke abantu bayeke ukuya kwintlobano zesini iintsuku ezimbini ngaphambi kokuhlaziywa kwebhu.
Kusuka kumaqela amabini, iisampuli zavavanywa kwimiqulu, isibalo-isibalo ngasinye kwisigxina se-seminal fluid, isibalo sembewu yesibalo, ipesenti yesidoda esashukumisayo, isantya kunye nesimo sesidoda.
I-Marijuana Ababhemayo babenesidumbu esincinane
Iziphumo zibonise ukuba zombini umthamo we-seminal fluid kunye nenani elipheleleyo lobuncwane ababhemayo be-marijuana babecala kakhulu kunokuba balawulwe ngamadoda. Ukwahlukana okuphawulekayo kwabonakala xa i-hyaluronic acid (i-anionic, i-nononsulated glycosaminoglycan isasazwa ngokubanzi kuwo wonke ama-tissue), kwaye isantya, kokubili nangemva kokuhlamba, kwavavanywa, kuphando lwafunyanwa.
"Umdaka ovela kumntu otshaya i-marijuana wayehamba ngokukhawuleza kakhulu," watsho uBurkman. "Ixesha lalingalunganga. Le ndoda iya kuba nokutshiswa ngaphambi kokuba ifike kwiqanda kwaye ayiyi kukwazi ukuchumisa."
Inobungozi Bomntu Okhulayo Bomda
Abaphandi bavuma ukuba amadoda amaninzi atshisa i-marijuana abelethe abantwana. "Amadoda athatyathwa kakhulu ayenzeka ngokuqhelekileyo akwazi ukuvelisa umnqweno we-ferlin, kwaye i-THC kwi-marijuana inokubangela ukuba baphumelele ekupheleleni," esho.
Ngokuphathelele umbuzo wokuba ubungakanani bendalo buyabuya xa ababhemayo beka ukusebenzisa i-marijuana: UBurman uthe umba awuzange ufundwe ngokufanelekileyo ukuze unike impendulo ecacileyo.
"I-THC ihlala igcinwe kwi-fat ebudeni bexesha elide, ngoko ke le nkqubo ingaba yulezi." Asinakutsho ukuba yonke into iya kubuyela kwisiqhelo. engozini. Ndiya kumcebisa ukuba nabani na ozama ukukhulelwa ukuba bangabhiyi inambuzane, kwaye oko kuya kuquka abafazi kunye namadoda. "
Ukuwela kwiMpawu zoManyolo
Uphando olwenziwe nguBurkman kunye nabahlobo bafumanisa ukuba ukusetyenziswa kwegciwane kungavimbela iinkqubo zokubonakalisa iikhemikhali ezenzeka ngexesha lokuchumisa. Ukusetyenziswa kweMarijuana kunokuphazamisa i-arachidonylethanolamide (AEA) ekhoyo kwiplasma yomntu, umjikelezo we-oviductal fluid, kunye ne-follicular fluid.
I-Sperm ibonakaliswe kulezi zixhobo zamanzi zokuzala njengoko zihamba zisuka kwisisu ukuya kwisiza sokukhulelwa kwi-oviduct. Abaphandi bafumene ukuba ukubonakaliswa kwe-AEA kunokulawulwa kwemisebenzi yesidoda efunekayo yokuchumisa emaphepheni okuzala, nokuba ukutshaya inambuzane kunokuchaphazela le nkqubo.
Ukuphazamisa Imisebenzi yeSperm
Olunye uphando lufumene ukuba ukusebenzisa i-marijuana kunokuphazamisa inkqubo ye-endocannabinoid (ECS), echaphazelekayo ekulawuleni ukuveliswa kwamadoda. Izifundo ezahlukeneyo kwi-vivo nase-in vitro zifumene ukuba i-marijuana iphazamisa i-hypothalamus-pituitary-gonadal axis, i-spermatogenesis, kunye nemisebenzi eyahlukeneyo yesidoda.
Olunye uphando lwe-endocannabinoid system lufumene ukuba i-marijuana inokuvimbela umsebenzi wokubonakalisa i-FAAH (i-fatty acid amide hydrolase) eyayifumene inendima ephambili kwiimpawu zokuzala, ezenza indima ekulawuleni amanyathelo amaninzi e-sperm biology.
Kuyacaca kulezi zifundo ezahlukeneyo zenzululwazi ukuba i-marijuana isebenzise iindidi ezahlukahlukeneyo ekuveliseni umntu kwaye akukho namnye kubo ophucula ukuzala.
Imithombo:
Du Plessis, SS, et al. "I-marijuana, i-phytocannabinoids, inkqubo ye-endocannabinoid, kunye nokuzala komntu." Umbhalo woNxibelelwano oluNcedisayo kunye neGenesis ngoNovemba 2015
Lewis, SE et al. "I-Endocannabinoids, i-sperm biology kunye nokuzala kwabantu." Uphando lwe-Pharmacological Agasti 2006
Schuel, H, et al. "Ubungqina bokuba i-anandamide-ukubonakalisa ilawula imisebenzi yoluntu yobuninzi efunekayo yokuchumisa." Ukuveliswa kweMali kunye noPhuhliso